CBR-Center of Breath Research, Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center, 66421 Homburg, Germany.
Outcomes Research Consortium, Cleveland, OH 44195, USA.
Molecules. 2022 Aug 17;27(16):5258. doi: 10.3390/molecules27165258.
Breath analysis provides great potential as a fast and non-invasive diagnostic tool for several diseases. Straight-chain aliphatic aldehydes were repeatedly detected in the breath of patients suffering from lung diseases using a variety of methods, such as mass spectrometry, ion mobility spectrometry, or electro-chemical sensors. Several studies found increased concentrations of exhaled aldehydes in patients suffering from lung cancer, inflammatory and infectious lung diseases, and mechanical lung injury. This article reviews the origin of exhaled straight-chain aliphatic aldehydes, available detection methods, and studies that found increased aldehyde exhalation in lung diseases.
呼气分析作为一种快速、非侵入性的诊断工具，在多种疾病的诊断中具有巨大的潜力。使用各种方法，如质谱、离子淌度谱或电化学传感器，反复在患有肺部疾病的患者的呼吸中检测到直链脂肪族醛。一些研究发现，患有肺癌、炎症和感染性肺部疾病以及机械性肺损伤的患者呼出的醛浓度升高。本文综述了呼出直链脂肪族醛的来源、现有的检测方法以及发现肺部疾病中醛呼出增加的研究。
