Department of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.
Molecules. 2022 Aug 22;27(16):5349. doi: 10.3390/molecules27165349.
Plants of the genus have been used throughout history for their emetic properties, rheumatism, and for the treatment of high blood pressure. However, inadvertent consumption of these plants, which resemble wild ramps, induces life-threatening side effects attributable to an abundance of steroidal alkaloids. Several of the steroidal alkaloids from spp. have been investigated for their ability to antagonize the Hedgehog (Hh) signaling pathway, a key pathway for embryonic development and cell proliferation. Uncontrolled activation of this pathway is linked to the development of various cancers; most notably, basal cell carcinoma and acute myeloid leukemia. Additional investigation of spp. may lead to the identification of novel alkaloids with the potential to serve as chemotherapeutics. is a relatively uncommon species of that resides in the southeastern regions of North America. The phytochemical profile of this plant remains largely unexplored; however, bioactive steroidal alkaloids, including cyclopamine, veratramine, veratridine, and verazine were identified in its extract. The structural elucidation and bioactivity assessment of steroidal alkaloids in lesser abundance within the extract of may yield potent Hh pathway inhibitors. This review seeks to consolidate the botanical and phytochemical information regarding
该属植物在历史上一直因其催吐特性、风湿和高血压治疗而被使用。然而，这些植物与野生鹿葱相似，人们在无意中食用这些植物会引起危及生命的副作用，这归因于它们含有丰富的甾体生物碱。从 spp. 中分离出的几种甾体生物碱已被研究用于拮抗 Hedgehog (Hh) 信号通路，这是胚胎发育和细胞增殖的关键通路。该通路的失控激活与各种癌症的发展有关，尤其是基底细胞癌和急性髓系白血病。对 spp. 的进一步研究可能会发现具有作为化疗药物潜力的新型生物碱。 是北美东南部地区相对较少见的物种。该植物的植物化学特征在很大程度上仍未被探索；然而，在其提取物中鉴定出了生物活性甾体生物碱，包括环巴胺、藜芦碱、藜芦定和长春胺。从 提取物中含量较少的甾体生物碱的结构阐明和生物活性评估可能会产生有效的 Hh 通路抑制剂。本文综述了有关 的植物学和植物化学信息。
