Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan.
Nutrients. 2022 Aug 10;14(16):3277. doi: 10.3390/nu14163277.
Dyslipidemia is an important risk factor for hypertension and is strongly associated with an elevated risk of cardiovascular diseases including atherosclerosis and stroke. In this study, we investigated correlations between lipid profiles, including triglycerides, total cholesterol (Chol), high-and low-density lipoprotein cholesterol (HDL-C/LDL-C), and Chol/HDL-C, and baseline and incident hypertension. A total of 26,965 subjects with 4 years of follow-up data were enrolled from the Taiwan Biobank. In the cross-sectional cohort, associations between the prevalence of hypertension and lipid profiles were examined in all study participants (n = 26,965). In the longitudinal cohort, these associations were further assessed in the participants without baseline hypertension (n = 21,454). Multivariable analysis revealed that those in the second quartile (Q2) of triglycerides (compared to Q1; odds ratio (OR), 1.402; p < 0.001); Q3 of triglycerides (compared to Q1; OR, 1.365; p < 0.001); Q4 of triglycerides (compared to Q1; OR, 1.617; p < 0.001); Q3 of HDL-C (compared to Q1; OR, 0.886; p = 0.042); Q4 of HDL-C (compared to Q1; OR, 0.819; p = 0.002); Q2 of Chol/HDL-C (compared to Q1; OR, 1.144; p = 0.042); Q3 of Chol/HDL-C (compared to Q1; OR, 1.149; p = 0.034); and Q4 of Chol/HDL-C (compared to Q1; OR, 1.225; p = 0.002) were significantly associated with incident hypertension. In summary, high Chol/HDL-C, low HDL-C, and high triglycerides were associated with a higher risk of incident hypertension in the enrolled Taiwanese participants.
血脂异常是高血压的一个重要危险因素，与包括动脉粥样硬化和中风在内的心血管疾病的风险升高密切相关。在这项研究中，我们研究了血脂谱（包括甘油三酯、总胆固醇（Chol）、高低密度脂蛋白胆固醇（HDL-C/LDL-C）和 Chol/HDL-C）与基线和新发高血压之间的相关性。共有 26965 名具有 4 年随访数据的受试者被纳入台湾生物库。在横断面队列中，在所有研究参与者（n=26965）中检查了高血压患病率与血脂谱之间的关联。在纵向队列中，在没有基线高血压的参与者（n=21454）中进一步评估了这些关联。多变量分析显示，与 Q1 相比，甘油三酯第二四分位数（Q2；优势比（OR），1.402；p<0.001）；Q3（OR，1.365；p<0.001）；Q4（OR，1.617；p<0.001）；Q3（OR，0.886；p=0.042）；Q4（OR，0.819；p=0.002）；Q2（OR，1.144；p=0.042）；Q3（OR，1.149；p=0.034）；和 Q4（OR，1.225；p=0.002）与新发高血压显著相关。总之，高 Chol/HDL-C、低 HDL-C 和高甘油三酯与台湾参与者新发高血压的风险增加相关。
