Department of Anesthesia, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China.
Department of Anesthesiology, Guizhou Medical University, Guiyang, China.
Clin Exp Hypertens. 2023 Dec 31;45(1):2195996. doi: 10.1080/10641963.2023.2195996.
It has been reported that there is a close correlation between triglycerides to high density lipoprotein cholesterol ratio (TG/HDL-C) and hypertension, but there are differences between different researches. The purpose of this study is to investigate the relationship between TG/HDL-C and hypertension in Chinese adults.
In this study, the open data for secondary analysis were obtained from DATADRYAD website (www.datadryad.org), and the raw data were from the Rich Healthcare Group Health. A total of 112 798 patients were enrolled in this study. The TG/HDL-C ratio was calculated as TG divided by HDL-C. Hypertension was defined as SBP ≥ 140 mmHg or DBP ≥ 90 mmHg. Logistic regression model was used to analyze the relationship between TG/HDL-C and hypertension. Sensitivity analysis and subgroup analysis were carried out to ensure the stability of the results.
After adjusting for confounding factors, the increase of TG/HDL-C was independently associated with the risk of hypertension (HR, 95% CI; 1.11,1.07 ~ 1.16). Compared with the lowest quartile (Q1), the risk of hypertension increased with the increase of TG/HDL-C (Q2, Q3 and Q4) [HR, 95% CI; 1.17 (1.06-1.29); 1.25 (1.13-1.38); 1.37 (1.24-1.52)]. Moreover, the relationship between TG/HDL-C and hypertension was not linear, but showed the saturation effect, and the slope of the curve decreases with the increase of TG/HDL-C. Results of subgroup analysis showed that there was a significant correlation among BMI (>=18.5 kg/m2, <24 kg/m2) and females.
TG/HDL-C is positively associated with increased risk of hypertension in Chinese adults, especially women and normal BMI.
已有报道称，甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）与高血压密切相关，但不同研究之间存在差异。本研究旨在探讨中国成年人 TG/HDL-C 与高血压之间的关系。
本研究中的二次分析开放数据来自于 DATADRYAD 网站（www.datadryad.org），原始数据来自于瑞驰医疗集团健康研究。共纳入 112798 例患者。TG/HDL-C 比值定义为 TG 除以 HDL-C。高血压定义为 SBP≥140mmHg 或 DBP≥90mmHg。采用 logistic 回归模型分析 TG/HDL-C 与高血压的关系。进行敏感性分析和亚组分析以确保结果的稳定性。
调整混杂因素后，TG/HDL-C 升高与高血压风险独立相关（HR，95%CI；1.11，1.071.16）。与最低四分位（Q1）相比，随着 TG/HDL-C 的升高，高血压的风险也随之增加（Q2、Q3 和 Q4）[HR，95%CI；1.17（1.061.29）；1.25（1.131.38）；1.37（1.241.52）]。此外，TG/HDL-C 与高血压之间的关系并非线性，而是呈现出饱和效应，随着 TG/HDL-C 的增加，曲线的斜率逐渐降低。亚组分析结果表明，在 BMI（>=18.5kg/m2，<24kg/m2）和女性中，TG/HDL-C 与高血压之间存在显著相关性。
在中国成年人中，TG/HDL-C 与高血压风险增加呈正相关，尤其是女性和正常 BMI 者。
