Zigmantaitė Vilma, Jonušaitė Eglė, Grigalevičiūtė Ramunė, Kučinskas Audrius, Treinys Rimantas, Navalinskas Antanas, Žvikas Vaidotas, Jakštas Valdas, Pudžiuvelytė Lauryna, Bernatonienė Jurga, Mačianskienė Regina, Jurevičius Jonas
Biological Research Center, Lithuanian University of Health Sciences, Tilžės St. 18/7, LT47181 Kaunas, Lithuania.
Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, Sukilėlių Ave. 15, LT50162 Kaunas, Lithuania.
Pharmaceuticals (Basel). 2022 Aug 10;15(8):982. doi: 10.3390/ph15080982.
The demand for the development of novel medicines with few side effects and no proarrhythmic properties is increasing. Extensive research on herbal extracts has been conducted with the expectation that the compounds will exert precise effects without harmful side effects. (Thunb.) Hyl. essential oil () possesses antiarrhythmic properties similar to those of class 1B antiarrhythmics, such as prolonging myocardial activation of the QRS complex and shortening the QT interval. In this study, we determined the kinetic profile of phytocompounds and the effects of on heart electrical activity and arterial blood pressure. For this study, we chose to use local breed pigs that were anaesthetized. The effects of an intravenous bolus of on ECG parameters, arterial blood pressure, heart rate variability, and blood levels of haematological and biochemical parameters were registered and evaluated. Following an intravenous injection of a bolus, exerted a vasodilatory effect, resulting in significant reductions in arterial blood pressure. EO also increased the heart rate and altered ECG parameters. The bolus of prolonged the QRS complex, shortened the QT interval, and nonmonotonically altered the PQ interval. After the administration of a bolus of , the activity of the autonomic nervous system was altered. This study confirms that possesses similar properties to class 1B antiarrhythmics and exerts a hypotensive effect; it reduces arterial blood pressure possibly by modulating peripheral vascular resistance.
对开发副作用少且无促心律失常特性的新型药物的需求日益增加。人们对草药提取物进行了广泛研究，期望这些化合物能发挥精确作用且无有害副作用。（Thunb.）Hyl.精油（）具有与1B类抗心律失常药物相似的抗心律失常特性，如延长QRS复合波的心肌激活时间和缩短QT间期。在本研究中，我们确定了植物化合物的动力学特征以及其对心脏电活动和动脉血压的影响。对于本研究，我们选择使用麻醉的本地品种猪。记录并评估了静脉推注对心电图参数、动脉血压、心率变异性以及血液学和生化参数血药浓度的影响。静脉注射推注后，产生了血管舒张作用，导致动脉血压显著降低。精油还增加了心率并改变了心电图参数。推注延长了QRS复合波，缩短了QT间期，并非单调地改变了PQ间期。推注给药后，自主神经系统的活动发生了改变。本研究证实具有与1B类抗心律失常药物相似的特性并发挥降压作用；它可能通过调节外周血管阻力来降低动脉血压。
