Farasati Far Bahareh, Naimi-Jamal Mohammad Reza, Safaei Maryam, Zarei Kimia, Moradi Marzieh, Yazdani Nezhad Hamed
Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Tehran 1684613114, Iran.
Department of Pharmacology, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta 99628, Turkey.
Polymers (Basel). 2022 Dec 12;14(24):5432. doi: 10.3390/polym14245432.
Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides.
在过去几年对药物递送系统（DDS）的研究中，基于天然聚合物的水凝胶因其固有特性和广泛的潜在应用而展现出诸多科学进展。虽然药物疗效和细胞毒性起着关键作用，但采用合适的药物递送系统对于在给药过程中保存药物并在靶位点发挥预期治疗效果至关重要。因此，药物递送技术可用于克服长时间将药物维持在生理相关血清浓度的困难。由于其出色的生物相容性，多糖作为用于推进药物递送系统的生物材料已得到深入研究。为了制备改良的药物递送系统，多糖可与不同分子交联，从而形成水凝胶。根据我们最近的研究结果，由于温度、pH值、葡萄糖或光等外部刺激，药物可在特定部位实现靶向递送。作为一种可调节的生物医学装置，水凝胶在制药和生物医学工程等相关健康领域的纳米技术应用中具有巨大潜力。本综述提供了水凝胶特性和功能的概述。我们着重讨论各种基于多糖制成的水凝胶系统在有效递送药物方面的潜力。
