Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Department of Biomedical Sciences, University of West Attica, 122 43 Athens, Greece.
Viruses. 2022 Aug 4;14(8):1724. doi: 10.3390/v14081724.
Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer but there are very limited published data concerning the genetic variations of this HPV type in oropharyngeal cancer. In the present study, the genetic variations of HPV16 gene sequences originated from a small cohort of Greek patients diagnosed with oropharyngeal cancer were assessed. The vast majority of the sequences clustered within the European variant branch. The T350G variation was found to be the predominant one. This finding may indicate the need for further studies that could explain the possible impact of this variant in the pathomechanisms of oropharyngeal cancer.
近年来，与高危型人乳头瘤病毒（HPV）16 型强烈相关的口咽鳞状细胞癌的发病率显著上升。HPV16 的遗传变异性在宫颈癌中已得到广泛研究，但有关这种 HPV 类型在口咽癌中的遗传变异的发表数据非常有限。在本研究中，评估了来自一小部分被诊断患有口咽癌的希腊患者的 HPV16 基因序列的遗传变异。绝大多数序列聚集在欧洲变异分支内。发现 T350G 变异是主要的变异。这一发现可能表明需要进一步的研究，以解释这种变异在口咽癌发病机制中的可能影响。
