Center for Global Health and Infectious Disease Research, University of South Florida, Tampa, FL 33612, USA.
Viruses. 2022 Aug 16;14(8):1786. doi: 10.3390/v14081786.
Chikungunya virus (CHIKV) is currently an urgent public health problem as high morbidity from the virus leaves populations with negative physical, social, and economic impacts. CHIKV has the potential to affect every organ of an individual, leaving patients with lifelong impairments which negatively affect their quality of life. In this review, we show the importance of CHIKV in research and public health by demonstrating the immunopathology of CHIKV as it presents in different organ systems. Papers used in this review were found on PubMed, using "chikungunya and [relevant organ system]". There is a significant inflammatory response during CHIKV infection which affects several organ systems, such as the brain, heart, lungs, kidneys, skin, and joints, and the immune response to CHIKV in each organ system is unique. Whilst there is clinical evidence to suggest that serious complications can occur, there is ultimately a lack of understanding of how CHIKV can affect different organ systems. It is important for clinicians to understand the risks to their patients.
基孔肯雅热病毒（CHIKV）是目前一个紧迫的公共卫生问题，因为该病毒的高发病率给人群带来了身体、社会和经济方面的负面影响。CHIKV 有可能影响个体的每一个器官，使患者留下终身损伤，从而对其生活质量产生负面影响。在本综述中，我们通过展示 CHIKV 在不同器官系统中的免疫病理学表现，展示了 CHIKV 在研究和公共卫生中的重要性。本文综述中使用的文献是在 PubMed 上使用“chikungunya 和 [相关器官系统]”搜索到的。在 CHIKV 感染过程中会发生明显的炎症反应，影响多个器官系统，如大脑、心脏、肺、肾脏、皮肤和关节，而 CHIKV 在每个器官系统中的免疫反应是独特的。虽然有临床证据表明可能会发生严重的并发症，但最终人们对 CHIKV 如何影响不同的器官系统缺乏了解。临床医生了解患者的风险很重要。
