• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

奥尼昂戈尼病毒的致病性和毒力：一种研究较少但具有大流行潜力的病毒。

Pathogenicity and virulence of O'nyong-nyong virus: A less studied with pandemic potential.

机构信息

A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

出版信息

Virulence. 2024 Dec;15(1):2355201. doi: 10.1080/21505594.2024.2355201. Epub 2024 May 26.

DOI:10.1080/21505594.2024.2355201
PMID:38797948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11135837/
Abstract

O'nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarthralgia in Africa. As climate change increases the geographical range of known and potential new vectors, recent data indicate a possibility for ONNV to spread outside of the African continent and grow into a greater public health concern. In this review, we summarise the current knowledge on ONNV epidemiology, host-pathogen interactions, vector-virus responses, and insights into possible avenues to control risk of further epidemics. In this review, the limited ONNV literature is compared and correlated to other findings on mainly Old World alphaviruses. We highlight and discuss studies that investigate viral and host factors that determine viral-vector specificity, along with important mechanisms that determine severity and disease outcome of ONNV infection.

摘要

奥尼昂尼昂病毒（ONNV）是一种被忽视的蚊媒α病毒，属于 科。已知该病毒可导致非洲散发性急性发热疾病和多发性关节炎。随着气候变化增加了已知和潜在新媒介的地理范围，最近的数据表明，ONNV 有可能传播到非洲大陆以外，并成为更大的公共卫生关注问题。在这篇综述中，我们总结了 ONNV 流行病学、宿主-病原体相互作用、媒介-病毒反应以及控制进一步流行风险的可能途径的现有知识。在这篇综述中，将有限的 ONNV 文献与主要旧世界甲病毒的其他发现进行了比较和关联。我们强调并讨论了研究病毒和宿主因素确定病毒-媒介特异性的研究，以及确定 ONNV 感染严重程度和疾病结局的重要机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/5fcea63e8cb7/KVIR_A_2355201_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/a9e16574d97f/KVIR_A_2355201_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/41aabdd32f78/KVIR_A_2355201_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/ccecbdee1925/KVIR_A_2355201_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/5fcea63e8cb7/KVIR_A_2355201_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/a9e16574d97f/KVIR_A_2355201_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/41aabdd32f78/KVIR_A_2355201_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/ccecbdee1925/KVIR_A_2355201_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c8/11135837/5fcea63e8cb7/KVIR_A_2355201_F0004_OC.jpg

相似文献

1
Pathogenicity and virulence of O'nyong-nyong virus: A less studied with pandemic potential.奥尼昂戈尼病毒的致病性和毒力：一种研究较少但具有大流行潜力的病毒。
Virulence. 2024 Dec;15(1):2355201. doi: 10.1080/21505594.2024.2355201. Epub 2024 May 26.
2
Analytical and clinical evaluation of a duplex RT-qPCR assay for the detection and identification of o'nyong-nyong and chikungunya virus.一种用于检测和鉴定奥尼昂戈尼翁和基孔肯雅病毒的双 RT-qPCR 分析和临床评估方法。
Emerg Microbes Infect. 2024 Dec;13(1):2429650. doi: 10.1080/22221751.2024.2429650. Epub 2024 Nov 24.
3
O'nyong-nyong fever: a neglected mosquito-borne viral disease.奥尼永永热：一种被忽视的蚊媒病毒病。
Pathog Glob Health. 2017 Sep;111(6):271-275. doi: 10.1080/20477724.2017.1355431. Epub 2017 Aug 22.
4
GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus.基孔肯雅热、奥尼昂奥尼昂热和马亚罗病毒 GloPID-R 报告，第 2 部分：奥尼昂奥尼昂热病毒的流行病学分布。
Antiviral Res. 2019 Dec;172:104611. doi: 10.1016/j.antiviral.2019.104611. Epub 2019 Sep 20.
5
Longitudinal [18F]FB-IL-2 PET Imaging to Assess the Immunopathogenicity of O'nyong-nyong Virus Infection.纵向 [18F]FB-IL-2 PET 成像评估奥尼昂戈尼昂病毒感染的免疫发病机制。
Front Immunol. 2020 May 12;11:894. doi: 10.3389/fimmu.2020.00894. eCollection 2020.
6
Vector competence of Anopheles stephensi for O'nyong-nyong virus: a risk for global virus spread.斯氏按蚊对奥尼昂戈尼翁病毒的媒介效能：病毒全球传播的风险。
Parasit Vectors. 2023 Apr 17;16(1):133. doi: 10.1186/s13071-023-05725-0.
7
Determinants of Chikungunya and O'nyong-Nyong Virus Specificity for Infection of and Mosquito Vectors.基孔肯雅热病毒和奥尼昂昂尼昂病毒感染 和 蚊虫媒介特异性的决定因素。
Viruses. 2023 Feb 21;15(3):589. doi: 10.3390/v15030589.
8
High-Sensitivity RT-LAMP for Molecular Detection of O'nyong-nyong ().用于奥尼昂-尼昂病毒分子检测的高灵敏度逆转录环介导等温扩增技术（） 。 （注：括号里内容原文缺失，这里保留原样）
Pathogens. 2024 Oct 11;13(10):892. doi: 10.3390/pathogens13100892.
9
Development of a Real-Time Reverse Transcription Polymerase Chain Reaction for O'nyong-nyong Virus and Evaluation with Clinical and Mosquito Specimens from Kenya.奥尼昂-尼昂病毒实时逆转录聚合酶链反应的开发及肯尼亚临床和蚊虫样本评估
Am J Trop Med Hyg. 2017 Jul;97(1):121-124. doi: 10.4269/ajtmh.17-0027.
10
GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects.基孔肯雅热、奥尼翁-奥尼翁和马亚罗病毒全球专门知识、创新和应对网络报告，第 5 部分：昆虫学方面。
Antiviral Res. 2020 Feb;174:104670. doi: 10.1016/j.antiviral.2019.104670. Epub 2019 Dec 5.

引用本文的文献

1
Invasive is a competent vector for O'nyong Nyong virus.侵袭性是奥尼昂尼昂病毒的一种有效传播媒介。
One Health. 2025 May 4;20:101062. doi: 10.1016/j.onehlt.2025.101062. eCollection 2025 Jun.
2
Proximity interactome of alphavirus replicase component nsP3 includes proviral host factors eIF4G and AHNAK.甲病毒复制酶组分nsP3的邻近相互作用组包括前病毒宿主因子eIF4G和AHNAK。
PLoS Pathog. 2025 Apr 7;21(4):e1013050. doi: 10.1371/journal.ppat.1013050. eCollection 2025 Apr.
3
Development of a virulent O'nyong'nyong challenge model to determine heterologous protection mediated by a hydrogen peroxide-inactivated chikungunya virus vaccine.

本文引用的文献

1
LDLR is used as a cell entry receptor by multiple alphaviruses.LDLR 被多种甲病毒用作细胞进入受体。
Nat Commun. 2024 Jan 20;15(1):622. doi: 10.1038/s41467-024-44872-5.
2
Role of macrophages in the onset, maintenance, or control of arthritis caused by alphaviruses.巨噬细胞在甲病毒引起的关节炎的发生、维持或控制中的作用。
Exp Biol Med (Maywood). 2023 Nov;248(22):2039-2044. doi: 10.1177/15353702231214261. Epub 2023 Dec 6.
3
FDA Approves First Chikungunya Vaccine.美国食品药品监督管理局批准首款基孔肯雅热疫苗。
开发一种恶性奥尼永永病毒攻击模型，以确定过氧化氢灭活的基孔肯雅病毒疫苗介导的异源保护作用。
PLoS Negl Trop Dis. 2025 Mar 17;19(3):e0012938. doi: 10.1371/journal.pntd.0012938. eCollection 2025 Mar.
4
Neuropathogenesis of Old World Alphaviruses: Considerations for the Development of Medical Countermeasures.旧大陆甲病毒的神经发病机制：医学应对措施研发的考量因素
Viruses. 2025 Feb 14;17(2):261. doi: 10.3390/v17020261.
5
Introduction of Vector-Borne Infections in Europe: Emerging and Re-Emerging Viral Pathogens with Potential Impact on One Health.欧洲媒介传播感染概述：对“同一健康”具有潜在影响的新出现和再次出现的病毒病原体
Pathogens. 2025 Jan 12;14(1):63. doi: 10.3390/pathogens14010063.
JAMA. 2023 Dec 19;330(23):2241. doi: 10.1001/jama.2023.23505.
4
FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design.FHL1 促进基孔肯雅热和奥尼昂奥尼翁病毒感染和发病机制，对甲病毒疫苗设计有影响。
Nat Commun. 2023 Oct 26;14(1):6605. doi: 10.1038/s41467-023-42330-2.
5
Updated roles of cGAS-STING signaling in autoimmune diseases.环状鸟苷酸-干扰素基因刺激物信号通路在自身免疫性疾病中的最新作用。
Front Immunol. 2023 Sep 14;14:1254915. doi: 10.3389/fimmu.2023.1254915. eCollection 2023.
6
In Vitro Analyses of the Multifocal Effects of Natural Alkaloids Berberine, Matrine, and Tabersonine against the O'nyong-nyong Arthritogenic Alphavirus Infection and Inflammation.天然生物碱小檗碱、苦参碱和长春多灵对奥尼昂永关节炎病毒感染及炎症的多焦点作用的体外分析
Pharmaceuticals (Basel). 2023 Aug 9;16(8):1125. doi: 10.3390/ph16081125.
7
Safety and immunogenicity of a single-shot live-attenuated chikungunya vaccine: a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial.一种单次接种的减毒活寨卡病毒疫苗的安全性和免疫原性：一项双盲、多中心、随机、安慰剂对照、3 期临床试验。
Lancet. 2023 Jun 24;401(10394):2138-2147. doi: 10.1016/S0140-6736(23)00641-4. Epub 2023 Jun 12.
8
Elucidating cellular interactome of chikungunya virus identifies host dependency factors.阐明基孔肯雅病毒的细胞相互作用组可鉴定宿主依赖性因素。
Virol Sin. 2023 Aug;38(4):497-507. doi: 10.1016/j.virs.2023.05.007. Epub 2023 May 12.
9
Vector competence of Anopheles stephensi for O'nyong-nyong virus: a risk for global virus spread.斯氏按蚊对奥尼昂戈尼翁病毒的媒介效能：病毒全球传播的风险。
Parasit Vectors. 2023 Apr 17;16(1):133. doi: 10.1186/s13071-023-05725-0.
10
Determinants of Chikungunya and O'nyong-Nyong Virus Specificity for Infection of and Mosquito Vectors.基孔肯雅热病毒和奥尼昂昂尼昂病毒感染 和 蚊虫媒介特异性的决定因素。
Viruses. 2023 Feb 21;15(3):589. doi: 10.3390/v15030589.