A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Virulence. 2024 Dec;15(1):2355201. doi: 10.1080/21505594.2024.2355201. Epub 2024 May 26.
O'nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarthralgia in Africa. As climate change increases the geographical range of known and potential new vectors, recent data indicate a possibility for ONNV to spread outside of the African continent and grow into a greater public health concern. In this review, we summarise the current knowledge on ONNV epidemiology, host-pathogen interactions, vector-virus responses, and insights into possible avenues to control risk of further epidemics. In this review, the limited ONNV literature is compared and correlated to other findings on mainly Old World alphaviruses. We highlight and discuss studies that investigate viral and host factors that determine viral-vector specificity, along with important mechanisms that determine severity and disease outcome of ONNV infection.
奥尼昂尼昂病毒(ONNV)是一种被忽视的蚊媒α病毒,属于 科。已知该病毒可导致非洲散发性急性发热疾病和多发性关节炎。随着气候变化增加了已知和潜在新媒介的地理范围,最近的数据表明,ONNV 有可能传播到非洲大陆以外,并成为更大的公共卫生关注问题。在这篇综述中,我们总结了 ONNV 流行病学、宿主-病原体相互作用、媒介-病毒反应以及控制进一步流行风险的可能途径的现有知识。在这篇综述中,将有限的 ONNV 文献与主要旧世界甲病毒的其他发现进行了比较和关联。我们强调并讨论了研究病毒和宿主因素确定病毒-媒介特异性的研究,以及确定 ONNV 感染严重程度和疾病结局的重要机制。