Wang Yanju, Liang Lihua, Liu Yingfeng, Li Peipei, Ren Jie
Department of Ultrasound, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
The Second Ward of Obstetrics, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Evid Based Complement Alternat Med. 2022 Aug 16;2022:4087406. doi: 10.1155/2022/4087406. eCollection 2022.
In this study, the application value of three-dimensional power Doppler ultrasound (3D-PDU) in fetal growth restriction (FGR) is explored. The retrospective cohort study enrolled pregnant women (with a gestational week of 11-13 + 6 weeks) who received routine health care in the obstetrics and gynecology clinic of our hospital from January 2020 to January 2021. The placentae were scanned using 3D-PDU, and the subjects were followed up until delivery. The fetuses were divided into the control group ( = 322) and FGR group ( = 44) according to their birth weight. There was no significant difference in nuchal translucency (NT), crown-rump length (CRL), and placental volume (PV) during the first trimester between the two groups ( > 0.05). Compared with the control group, the FGR group showed significantly lower levels of vascularisation index (VI), flow index (FI), and vascularisation flow index (VFI) and a higher incidence of fetal distress and neonatal asphyxia ( < 0.05). The FGR group showed a longer gestational week at birth, a higher probability of cesarean section, and a lower 5-minute Apgar score than the control group ( < 0.05). The VI, FI, and VFI of the control group were significantly higher than those of the FGR group. Pearson analysis showed that birth weight was positively correlated with VI and FI ( < 0.05). 3D-PDU assesses the blood perfusion of the fetus and placenta in the first trimester and predicts the pregnancy outcome, which shows great potential in the early diagnosis of FGR.
本研究探讨三维能量多普勒超声（3D-PDU）在胎儿生长受限（FGR）中的应用价值。回顾性队列研究纳入了2020年1月至2021年1月在我院妇产科门诊接受常规保健的孕妇（孕周为11-13⁺⁶周）。使用3D-PDU对胎盘进行扫描，并对受试者进行随访直至分娩。根据出生体重将胎儿分为对照组（n = 322）和FGR组（n = 44）。两组孕早期的颈项透明层（NT）、头臀长（CRL）和胎盘体积（PV）无显著差异（P > 0.05）。与对照组相比，FGR组的血管化指数（VI）、血流指数（FI）和血管化血流指数（VFI）水平显著降低，胎儿窘迫和新生儿窒息的发生率更高（P < 0.05）。FGR组出生时孕周更长，剖宫产概率更高，5分钟阿氏评分低于对照组（P < 0.05）。对照组的VI、FI和VFI显著高于FGR组。Pearson分析显示出生体重与VI和FI呈正相关（P < 0.05）。3D-PDU可评估孕早期胎儿和胎盘的血流灌注并预测妊娠结局，在FGR的早期诊断中显示出巨大潜力。
