Emmi Aron, Antonini Angelo, Sandre Michele, Baldo Andrea, Contran Martina, Macchi Veronica, Guidolin Diego, Porzionato Andrea, De Caro Raffaele
Department of Neurosciences, Institute of Human Anatomy, University of Padova, Padua, Italy.
Center for Neurodegenerative Disease Research (CESNE), University of Padova, Padua, Italy.
Front Neurosci. 2022 Aug 9;16:945574. doi: 10.3389/fnins.2022.945574. eCollection 2022.
The human Subthalamic Nucleus (STh) is a diencephalic lens-shaped structure located ventrally to the thalamus and functionally implicated in the basal ganglia circuits. Despite recent efforts to characterize the neurochemical and functional anatomy of the STh, little to no information is available concerning the expression and distribution of receptors belonging to the dopaminergic and purinergic system in the human STh. Both systems are consistently implicated in basal ganglia physiology and pathology, especially in Parkinson's Disease, and represent important targets for the pharmacological treatment of movement disorders. Here, we investigate the topography and distribution of A adenosine and D dopamine receptors in the human basal ganglia and subthalamic nucleus. Our findings indicate a peculiar topographical distribution of the two receptors throughout the subthalamic nucleus, while colocalization between the receptors opens the possibility for the presence of AR- DR heterodimers within the dorsal and medial aspects of the structure. However, further investigation is required to confirm these findings.
人类丘脑底核（STh）是一个位于丘脑腹侧的间脑透镜状结构，在功能上与基底神经节回路相关。尽管最近人们努力对丘脑底核的神经化学和功能解剖进行表征，但关于人类丘脑底核中多巴胺能和嘌呤能系统受体的表达和分布，几乎没有可用信息。这两个系统一直与基底神经节的生理和病理相关，尤其是在帕金森病中，并且是运动障碍药物治疗的重要靶点。在这里，我们研究了人类基底神经节和丘脑底核中A类腺苷受体和D类多巴胺受体的拓扑结构和分布。我们的研究结果表明，这两种受体在整个丘脑底核中呈现出特殊的拓扑分布，而受体之间的共定位为该结构背侧和内侧存在AR-DR异二聚体提供了可能性。然而，需要进一步研究来证实这些发现。
