Department of Psychiatry, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310013, China.
Department of Emergency, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310013, China.
Biomed Res Int. 2022 Aug 16;2022:3394978. doi: 10.1155/2022/3394978. eCollection 2022.
Existing antipsychotic medications may alleviate the majority of patients' symptoms, but they have no discernible impact on improving social function and quality of life. Psychotherapy is required for the treatment of schizophrenia. However, contemporary psychotherapy technology intervention techniques are limited to a single intervention, and there is a lack of holistic and complete intervention approaches. Social cognition and interaction training is a comprehensive therapy strategy that has been employed in clinical practice; however, the therapeutic efficacy has been inconsistently reported. As a result, we included controlled clinical trials for meta-analysis in order to carefully assess the efficacy of this therapy.
This meta-analysis searched all RCT literatures related to social cognitive interaction training (SCIT) published before April 2022 and assessed the effect of this method in the treatment of schizophrenia. The data in the literatures were combined, and the standardized mean difference (SMD) and mean difference (MD) with 95% confidence interval (95% CI) were calculated to predict the negative symptom score, positive symptom score, PANSS score, and social function score of the patients after treatment.
14 RCT studies including 1167 inpatients with schizophrenia were included in this study using a retrospective observational study method, including 590 patients treated with SCIT and 577 patients treated with treatment as usual (TAU). The pooled analysis showed that patients after SCIT had lower negative symptom scores (SMD = -1.66, 95% CI (-2.32, -1.00), < 0.0001), lower positive symptom scores (MD = -4.03, 95% CI (-7.69, -0.36), = 0.03), lower PANSS total scores (MD = -6.33, 95% CI (-12.43, -0.23), = 0.02), and higher social functioning scores (SMD = 0.77, 95% CI (0.34, 1.20), < 0.001) than those after TAU.
Our findings support that SCIT is helpful to improve the relief of symptoms and the improvement of social function in patients with schizophrenia, providing a basis for the application of SCIT in hospitalized patients and community patients, and can guide the treatment and intervention of patients with schizophrenia.
现有的抗精神病药物可能缓解大多数患者的症状，但对改善社会功能和生活质量没有明显影响。精神分裂症的治疗需要心理治疗。然而，当代心理治疗技术干预手段仅限于单一干预，缺乏整体和完整的干预方法。社会认知与互动训练是一种已应用于临床实践的综合治疗策略；然而，其治疗效果的报道并不一致。因此，我们纳入了对照临床试验进行荟萃分析，以仔细评估该疗法的疗效。
本荟萃分析检索了截至 2022 年 4 月发表的所有与社会认知互动训练（SCIT）相关的 RCT 文献，并评估了该方法在精神分裂症治疗中的效果。对文献中的数据进行合并，并计算标准化均数差（SMD）和均数差（MD）及其 95%置信区间（95%CI），以预测治疗后患者的阴性症状评分、阳性症状评分、PANSS 评分和社会功能评分。
采用回顾性观察研究方法，共纳入 14 项 RCT 研究，共纳入 1167 例住院精神分裂症患者，其中 590 例接受 SCIT 治疗，577 例接受常规治疗（TAU）。汇总分析显示，SCIT 治疗后患者的阴性症状评分较低（SMD=-1.66，95%CI（-2.32，-1.00），<0.0001），阳性症状评分较低（MD=-4.03，95%CI（-7.69，-0.36），=0.03），PANSS 总分较低（MD=-6.33，95%CI（-12.43，-0.23），=0.02），社会功能评分较高（SMD=0.77，95%CI（0.34，1.20），<0.001）。
我们的研究结果支持 SCIT 有助于改善精神分裂症患者的症状缓解和社会功能改善，为 SCIT 在住院患者和社区患者中的应用提供了依据，可指导精神分裂症患者的治疗和干预。
