Nasra Mohamed, Maingard Julian Tam, Hall Jonathan, Mitreski Goran, Kuan Kok Hong, Smith Paul D, Russell Jeremy H, Jhamb Ashu, Brooks Duncan Mark, Asadi Hamed
Monash Health, Clayton, Victoria, Australia.
Interventional Neuroradiology Unit, Monash Imaging, Monash Health, Clayton, Victoria, Australia.
Interv Neuroradiol. 2024 Feb;30(1):86-93. doi: 10.1177/15910199221122854. Epub 2022 Aug 25.
Two major studies, The International Subarachnoid Aneurysm Trial and the Barrow Ruptured Aneurysm Trial, compare the long-term outcomes of clipping and coiling. Although these demonstrated coiling's initial benefits, rebleeding and retreatment rates as well as converging patient outcomes sparked controversy regarding its durability. This article will critically examine the available evidence for and against clipping and coiling of intracranial aneurysms. Critics of endovascular treatment state that the initial benefit seen with endovascular coiling decreases over the duration of follow-up and eventually functional outcomes of both treatment modalities are similar. Combined with the increased rate of retreatment and rebleeding, these trials reveal that coiling is not as durable and not as effective as a long-term treatment compared to clipping. Also, due to the cost of devices following endovascular treatment and prolonged hospitalization following clipping, the financial burden has been considered controversial.
SUMMARY/KEY MESSAGES: Short-term outcomes reveal better morbidity and mortality outcomes following coiling. Despite the higher rates of retreatment and rebleeding with coiling, there was no significant change in functional outcomes following retreatment. Furthermore, examining more recent trials reveals a decreased rate of recurrence and rebleeding with improved technology and expertise. Functional outcomes deteriorate for both cohorts over time while recent results revealed improved long-term cognitive outcomes and levels of health-related quality of life after coiling in comparison to clipping. The expense of longer hospital stays following clipping must be balanced against the expense of endovascular devices in coiling.
两项主要研究,即国际蛛网膜下腔动脉瘤试验和巴罗破裂动脉瘤试验,比较了夹闭术和血管内栓塞术的长期疗效。尽管这些研究显示了血管内栓塞术的初始益处,但再出血和再次治疗率以及患者预后趋同引发了关于其持久性的争议。本文将批判性地审视支持和反对颅内动脉瘤夹闭术和血管内栓塞术的现有证据。血管内治疗的批评者指出,血管内栓塞术所见的初始益处会在随访期间逐渐降低,最终两种治疗方式的功能预后相似。结合再次治疗率和再出血率的增加,这些试验表明,与夹闭术相比,血管内栓塞术作为一种长期治疗方法,持久性较差且效果不佳。此外,由于血管内治疗后器械的成本以及夹闭术后住院时间延长,经济负担一直存在争议。
总结/关键信息:短期预后显示血管内栓塞术后的发病率和死亡率预后更佳。尽管血管内栓塞术的再次治疗率和再出血率较高,但再次治疗后的功能预后并无显著变化。此外,对近期试验的研究表明,随着技术和专业水平的提高,复发率和再出血率有所降低。随着时间的推移,两个队列的功能预后均恶化,而近期结果显示,与夹闭术相比,血管内栓塞术后的长期认知预后和健康相关生活质量水平有所改善。夹闭术后较长住院时间的费用必须与血管内栓塞术中器械的费用相权衡。