Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Headache. 2022 Sep;62(8):977-988. doi: 10.1111/head.14380. Epub 2022 Aug 26.
To estimate the associations of physical activity (PA) levels with migraine subtypes.
Physical activity has been associated with reduced migraine prevalence, but less is known about its relationship with migraine subtypes and PA levels as recommended by World Health Organization (WHO).
In this cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), we estimated the odds ratios (ORs) of migraine with aura (MA) and migraine without aura (MO), compared to participants without headaches, according to PA levels in the leisure time (LTPA), commuting time (CPA), and combined PA domains.
In total, 2773 participants provided complete data, 1556/2773 (56.1%) were women, mean (SD) age of 52.3 (9.1) years. In this study's sample, 1370/2773 (49.4%) participants had overall migraine, 480/2773 (17.3%) had MA, and 890/2773 (32.0%) had MO. In the LTPA domain, there were reduced odds of MA (OR 0.72, 95% confidence interval [CI] 0.53-0.96; p = 0.030) and MO (OR 0.71, 95% CI 0.56-0.90; p = 0.005) in participants who met the WHO PA guidelines after adjustment for confounder variables. In the analyses stratified by intensity, moderate LTPA was associated with reduced odds of MA (OR 0.56, 95% CI 0.320-0.99; p = 0.049), while vigorous LTPA was associated with reduced odds of MO (OR 0.55, 95% CI 0.395-0.77; p = 0.001). There were no significant associations between migraine subtypes and CPA or combined PA domains. In the whole migraine sample, meeting the WHO PA guidelines in the LTPA (OR 0.275, 95% CI 0.083-0.90; p = 0.034), CPA (OR 0.194, 95% CI 0.064-0.58; p = 0.004), and combined domains (OR 0.115, 95% CI 0.032-0.41; p = 0.001) was associated with reduced odds of daily migraine attack frequency.
Meeting the WHO PA guidelines for LTPA, but not CPA or combined PA domains, is associated with lower migraine occurrence. Moderate LTPA favors MA reduction, while vigorous LTPA favors MO reduction.
评估体力活动（PA）水平与偏头痛亚型的关联。
体力活动与偏头痛患病率降低有关，但对于体力活动与偏头痛亚型和世界卫生组织（WHO）推荐的体力活动水平之间的关系，人们了解较少。
在巴西成人健康纵向研究（ELSA-Brasil）的这项横断面分析中，我们根据休闲时间（LTPA）、通勤时间（CPA）和综合 PA 领域的 PA 水平，比较了有先兆偏头痛（MA）和无先兆偏头痛（MO）与无头痛参与者的偏头痛比值比（OR）。
共有 2773 名参与者提供了完整的数据，其中 1556/2773（56.1%）为女性，平均（SD）年龄为 52.3（9.1）岁。在本研究的样本中，1370/2773（49.4%）的参与者患有偏头痛，480/2773（17.3%）患有 MA，890/2773（32.0%）患有 MO。在 LTPA 领域，调整混杂变量后，符合世界卫生组织 PA 指南的参与者患 MA（OR 0.72，95%置信区间 [CI] 0.53-0.96；p=0.030）和 MO（OR 0.71，95% CI 0.56-0.90；p=0.005）的几率降低。在按强度分层的分析中，中度 LTPA 与 MA 几率降低相关（OR 0.56，95% CI 0.320-0.99；p=0.049），而剧烈 LTPA 与 MO 几率降低相关（OR 0.55，95% CI 0.395-0.77；p=0.001）。偏头痛亚型与 CPA 或综合 PA 领域之间没有显著关联。在整个偏头痛样本中，符合世界卫生组织 PA 指南的 LTPA（OR 0.275，95% CI 0.083-0.90；p=0.034）、CPA（OR 0.194，95% CI 0.064-0.58；p=0.004）和综合领域（OR 0.115，95% CI 0.032-0.41；p=0.001）与每日偏头痛发作频率降低的几率降低相关。
符合世界卫生组织关于 LTPA 的 PA 指南，但不符合 CPA 或综合 PA 领域的指南，与偏头痛的发生几率降低有关。中度 LTPA 有利于 MA 减少，而剧烈 LTPA 有利于 MO 减少。
