偏头痛与动脉僵硬度：巴西成年人健康纵向研究（ELSA-Brasil）

Migraine and Arterial Stiffness in the Brazilian Longitudinal Study of Adult Health: ELSA-Brasil.

机构信息

Escola de Medicina, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Paraná, Brazil.

Hospital Universitário, Universidade De São Paulo, São Paulo, Brazil.

出版信息

Am J Hypertens. 2020 Apr 29;33(5):458-464. doi: 10.1093/ajh/hpaa005.

DOI:10.1093/ajh/hpaa005

PMID:31907516

Abstract

BACKGROUND

The mechanisms that underlie the link between migraine and cardiovascular diseases are not clear and arterial stiffness could play a role in that association. We analyzed the association between migraine and vascular stiffness measured by carotid-to-femoral pulse wave velocity (PWV-cf).

METHODS

In a cross-sectional analysis of a well-defined population from the Longitudinal Study of Adult Health (ELSA-Brasil) with complete and validated information about migraine and aura according to the International Headache Society criteria, the association between arterial stiffness measured by PWV-cf was tested with multiple linear regression models [β (95% CI)] comparing migraine without aura (MO) and migraine with aura (MA) to the reference group no-migraine (NM). Subsequent adjustments were made for mean arterial pressure, age, sex, education level, physical activity, alcohol use, diabetes mellitus, smoking, antihypertensive medication, body mass index, waist circumference, triglycerides, and LDL-c level to test the independence of the association between migraine status and pulse wave velocity.

RESULTS

We studied 4,649 participants, 2,521 women (25.7% MO and 15% MA) and 2,128 men (11% MO and 4.3% MA). In NM, MO, and MA standard PWV-cf were 8.67 (±1.71) 8.11 (±1.31) and 8.01 (±1.47) m/s, respectively. Unadjusted PWV-cf differed between NM, MA, and MO (P < 0.001). After adjustment for mean arterial pressure PWV-cf in NM did not differ anymore from MA (P = 0.525) and MO (P = 0.121), respectively. Fully adjusted models also yielded nonsignificant coefficients β (95% CI) -0.079 (-0.280; 0.122) and -0.162 (-0.391; 0.067) for MO and MA, respectively.

CONCLUSION

In this large cohort of middle-aged adults, aortic PWV was not associated with migraine.

摘要

背景

偏头痛与心血管疾病之间的关联的机制尚不清楚，而动脉僵硬可能在这种关联中起作用。我们分析了偏头痛与通过颈动脉-股动脉脉搏波速度（PWV-cf）测量的血管僵硬之间的关系。

方法

在一项对来自纵向成人健康研究（ELSA-Brasil）的明确人群的横断面分析中，根据国际头痛协会的标准，偏头痛和先兆偏头痛的完全和验证信息均完整，通过多元线性回归模型测试了 PWV-cf 测量的动脉僵硬之间的关系[β（95%置信区间）]，将无先兆偏头痛（MO）和有先兆偏头痛（MA）与无偏头痛（NM）参考组进行比较。为了测试偏头痛状态与脉搏波速度之间的关联的独立性，还进行了平均动脉压、年龄、性别、教育水平、体力活动、饮酒、糖尿病、吸烟、降压药物、体重指数、腰围、甘油三酯和 LDL-c 水平的调整。

结果

我们研究了 4649 名参与者，其中 2521 名女性（25.7%为 MO，15%为 MA）和 2128 名男性（11%为 MO，4.3%为 MA）。NM、MO 和 MA 的标准 PWV-cf 分别为 8.67（±1.71）、8.11（±1.31）和 8.01（±1.47）m/s。NM、MA 和 MO 之间的未调整 PWV-cf 存在差异（P<0.001）。在调整平均动脉压后，NM 与 MA（P=0.525）和 MO（P=0.121）之间的 PWV-cf 差异不再显著。完全调整后的模型也得出了无统计学意义的系数β（95%置信区间）-0.079（-0.280；0.122）和-0.162（-0.391；0.067），分别用于 MO 和 MA。