Mena Leandro D, Baumgartner María T
QUIAMM-INBIOTEC-Departamento de Química, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Mar del Plata B7600, Argentina.
INFIQC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000, Argentina.
J Am Chem Soc. 2022 Sep 7;144(35):15922-15927. doi: 10.1021/jacs.2c05602. Epub 2022 Aug 26.
Proton-coupled electron transfer (PCET) reactions are crucial for the optimal functioning of a broad scope of chemical and biological processes. In this report, we present an unprecedented type of concerted PCET (cPCET), in which a chalcogen atom acts as the electron donor. The nature of this mechanism is key for understanding the reactivity of different radical-trapping antioxidants having heavy chalcogens (S, Se, or Te) in their structures. Moreover, this chalcogen-assisted cPCET is likely to be occurring in multiple systems of biological interest.
质子耦合电子转移（PCET）反应对于广泛的化学和生物过程的最佳运行至关重要。在本报告中，我们展示了一种前所未有的协同PCET（cPCET）类型，其中一个硫族原子充当电子供体。这种机制的本质对于理解结构中含有重硫族元素（S、Se或Te）的不同自由基捕获抗氧化剂的反应性至关重要。此外，这种硫族元素辅助的cPCET可能在多个具有生物学意义的系统中发生。
