Marzoev A I, Panasenko O M, Andriushchenko A P
Probl Endokrinol (Mosk). 1987 Mar-Apr;33(2):75-8.
An increase in the fluidity of membranes in experimental hyperthyreosis of rats was shown by the registration of EPR-signals labeled with spin probe (5-dosilsterate). Modifications of the physical state of erythrocytic membranes induced in vivo by thyroid hormones were shown to depend on the fatty acid composition of food fats. Thus, the simulation of hyperthyreosis against a background of a diet with more viscous fats (pork lard) was accompanied by a decrease in the fluidity of erythrocytic membranes, whereas food enrichment with polyunsaturated fats (sunflower oil) inhibited the effect of hyperthyreosis on the structural state of membranes. An increase in the fluidity of membranes also resulted from the incubation of erythrocytes of normal animals with physiological concentrations of triiodothyronine (10(-9) M). Under these conditions adding up of thyroxine (10(-7) M) prevented the effect of the first hormone on the structure of membranes. It was assumed that a modifying effect of thyroid hormones in vivo was partially based on rearrangements in the fatty acid composition of membrane lipids.
用自旋探针（5 - 二硬脂酸酯）标记的电子顺磁共振信号记录表明，大鼠实验性甲状腺功能亢进时膜流动性增加。甲状腺激素在体内诱导的红细胞膜物理状态的改变被证明取决于食物脂肪的脂肪酸组成。因此，在食用更粘稠脂肪（猪油）的饮食背景下模拟甲状腺功能亢进，会伴随着红细胞膜流动性的降低，而富含多不饱和脂肪（葵花籽油）的食物则抑制了甲状腺功能亢进对膜结构状态的影响。正常动物的红细胞与生理浓度的三碘甲状腺原氨酸（10(-9) M）孵育也会导致膜流动性增加。在这些条件下，添加甲状腺素（10(-7) M）可阻止第一种激素对膜结构的影响。据推测，甲状腺激素在体内的调节作用部分基于膜脂脂肪酸组成的重排。
