Shikhsaidov I I
Probl Endokrinol (Mosk). 1978 Sep-Oct;24(5):29-36.
A method of acceleration kinetocardiography was applied to the study of the effect of obsidan on the contractile funciton of the heart in 153 patients suffering from toxic goiter with the visceropathic stage of the disease. Results of single and prolonged (up to 30-day) use of obsidan, and also effects in case of its combined with mercazolil corglycon or prednisolone prescription were assessed. The results obtained indicated that chronotropic action alone was expressed in case of oral single administration of obsidan, whereas its intravenous injection could cause suppression of the contractile function of the myocardium. Prolonged oral use of obsidan or of its combination with mercazolil was accompanied by a negative inotropic action on the myocardium. This could be prevented by a simultaneous prescription of corglycon or prednisolone. In prolonged use of obsidan one should take into consideration the initial condition of the intracardiac hemodynamics, since the latter is normalized in the presence of the hyperdynamia syndrome, but in case of the initial hypodynamic the treatment aggravates the hypodynamia syndrome.
应用加速心动图描记法对153例处于疾病内脏病变期的毒性甲状腺肿患者进行研究，以探讨黑曜石对心脏收缩功能的影响。评估了单次及长期（长达30天）使用黑曜石的效果，以及其与甲巯咪唑、强心苷或泼尼松龙联合使用时的效果。所得结果表明，口服单次给予黑曜石时仅表现出变时作用，而静脉注射则可导致心肌收缩功能受到抑制。长期口服黑曜石或其与甲巯咪唑联合使用时，会对心肌产生负性肌力作用。同时给予强心苷或泼尼松龙可预防这种情况。在长期使用黑曜石时，应考虑心脏内血流动力学的初始状况，因为在存在动力亢进综合征时其可恢复正常，但在初始动力不足的情况下，治疗会加重动力不足综合征。
