Litvitskiĭ P F, Levchenko N F, Ol'binskaia L I
Kardiologiia. 1981 Jan;21(1):90-2.
The peculiarities of the preventive use of obsidan administered by injection and electrophoresis were studied in experiments on rats with a model of transitory coronary insufficiency. A high efficacy of obsidan was demonstrated irrespective of the route of its administration into the body. This was manifested by a decrease in the rate of cardiac contractions in intact animals and depression of hyperkinetic cardiac reaction in the initial period of myocardial ischemia. The unfavourable inotropic and the antiarrhythmic effects of the agent were less in electrophoretic administration than in injection.
在建立短暂性冠状动脉供血不足模型的大鼠实验中，研究了注射和电泳给药方式预防使用黑曜石的特点。结果表明，无论通过何种途径给药，黑曜石都具有高效性。这表现为在完整动物中，心脏收缩速率降低，以及在心肌缺血初期，过度活跃的心脏反应受到抑制。与注射给药相比，电泳给药时该药物的不良变力作用和抗心律失常作用较小。
