Hennig B, Scholz F, Wolf G
Pharmazie. 1987 Mar;42(3):162-4.
The hydrolytic decomposition of hydrochlorothiazide (1) in an optimized dispensing with polyethyleneglycol 400/ethanol as solvent led to an equilibrium in the isothermic short-term test as well as in the long-term stability test. Corresponding equilibrium concentrations were obtained for forward and back reaction. When comparing the precalculated equilibrium values with the long-term results the evaluation after Van't Hoff proved superior compared with an evaluation after the Arrhenius plot which is only applicable when the equilibrium concentrations are taken into consideration. By adding the decomposition product aminodisulfamide (2) the hydrolysis of 1 can be inhibited completely.
在以聚乙二醇400/乙醇为溶剂的优化配方中，氢氯噻嗪（1）的水解分解在等温短期试验和长期稳定性试验中均达到平衡。得到了正反应和逆反应的相应平衡浓度。将预先计算的平衡值与长期结果进行比较时，范特霍夫评估法比仅在考虑平衡浓度时适用的阿累尼乌斯图评估法更优越。通过添加分解产物氨基二磺酰胺（2），可以完全抑制1的水解。
