Hennig B, Scholz F, Peinhardt G
Pharmazie. 1986 Aug;41(8):565-6.
Studies of the stability of hydrochlorothiazide (1) in N-methylacetamide prove that a temperature dependent equilibrium is found in the isothermic short-term test as well as in the longterm stability test. Whereas the kinetic reaction evaluation after Arrhenius doesn't allow a forecast, the 25 degrees C-values, extrapolated after the Van't Hoff-equation, were confirmed using the long-term test. By adding the decomposition product aminodisulfamide (2) the hydrolysis is restricted.
对氢氯噻嗪（1）在N - 甲基乙酰胺中的稳定性研究表明，在等温短期试验以及长期稳定性试验中均发现了温度依赖性平衡。虽然根据阿累尼乌斯方程进行的动力学反应评估无法进行预测，但通过范特霍夫方程外推得到的25℃时的值在长期试验中得到了证实。通过添加分解产物氨基二硫酰胺（2），水解受到限制。
