Hennig B, Scholz F, Hennig D
Pharmazie. 1985 Jul;40(7):467-9.
Checking-up the stability of hydrochlorothiazid tablets (Disalunil), chemical and especially pharmaceutical-technological analyses were forming part of the adequate test programme. The pharmaceutical and chemical properties of the Disalunil tablets will be regarded as sufficient ones at normal conditions of their storage. In case the tablets will be stored, however, in their original packing under conditions of an increased humidity or with additional water, the water sorption will result in prolonged disintegration rates as well as in a reduced radial breaking strength and dissolution rate. This significant depreciation of the drug cannot be recognized by chemical-analytical methods.
为检查氢氯噻嗪片（双氢氯散疾）的稳定性，化学分析尤其是药物工艺分析构成了适当测试程序的一部分。在正常储存条件下，双氢氯散疾片的药物和化学性质被认为是足够稳定的。然而，如果片剂在原包装中于湿度增加的条件下或有额外水分的情况下储存，吸水会导致崩解速率延长，以及径向断裂强度和溶出速率降低。这种药物的显著变质无法通过化学分析方法识别。
