Jeyasingham M D, Pratt O E, Burns A, Shaw G K, Thomson A D, Marsh A
Psychol Med. 1987 May;17(2):311-8. doi: 10.1017/s0033291700024843.
Erythrocyte transketolase activation by thiamin diphosphate has been studied in elderly patients with moderate or severe chronic dementia, acute alcoholic admissions and chronic alcoholics with evidence of brain damage, mostly of the Wernicke-Korsakoff type. Significantly more patients in each group than controls showed abnormal activation of transketolase, not only by 0.3 mM thiamin diphosphate (TDP) but also in further activation by increase to 3 mM. This indicated the presence in a proportion of the alcoholic and the demented patients of an abnormal enzyme variant, similar to that previously found in vitro. The modified transketolase activation test may warn not only of marginal thiamin deficiency but also independently, of susceptibility to brain damage in patients at risk.
已对患有中度或重度慢性痴呆的老年患者、急性酒精中毒入院患者以及有脑损伤证据（主要为韦尼克 - 科尔萨科夫型）的慢性酗酒者进行了硫胺二磷酸对红细胞转酮醇酶激活作用的研究。与对照组相比，每组中显著更多的患者不仅在0.3 mM硫胺二磷酸（TDP）作用下，而且在增加至3 mM时进一步激活，均表现出转酮醇酶的异常激活。这表明在一部分酗酒者和痴呆患者中存在一种异常酶变体，类似于先前在体外发现的变体。改良的转酮醇酶激活试验不仅可以警示边缘性硫胺缺乏，还可以独立地警示有风险患者对脑损伤的易感性。
