Ullrich R L, Jernigan M C, Satterfield L C, Bowles N D
Radiat Res. 1987 Jul;111(1):179-84.
The present studies were undertaken to examine the time-dose relationships for the induction of lung adenocarcinomas and mammary adenocarcinomas in female BALB/c mice following gamma irradiation. Twelve-week-old female BALB/c/An NBd mice were irradiated with 137Cs gamma rays, and lifetime tumor incidences following high-dose-rate, low-dose-rate, or fractionated exposure regimens were compared. Analysis of the results indicated that the data could be fitted by linear-quadratic dose-response models for the induction of both tumors following acute doses and a linear model with a slope similar to that for the linear portion of the linear quadratic following low-dose-rate exposure regimens. When doses were fractionated the response was dependent upon the dose per fraction. If the dose per fraction was a dose which was predominantly on the linear portion of the acute dose response curve, then the response was linear and similar to that after low-dose-rate exposures. If the dose per fraction was in a region where the quadratic portion of the acute dose-response was significant, then the tumor incidence was higher than that following low-dose-rate exposures.
本研究旨在探讨γ射线照射后雌性BALB/c小鼠诱发肺腺癌和乳腺腺癌的时间-剂量关系。对12周龄雌性BALB/c/An NBd小鼠进行137Csγ射线照射，并比较高剂量率、低剂量率或分次照射方案后的终生肿瘤发生率。结果分析表明，急性剂量照射后诱发这两种肿瘤的数据可用线性二次剂量反应模型拟合，低剂量率照射方案后的数据可用斜率与线性二次模型线性部分相似的线性模型拟合。当剂量分次给予时，反应取决于每次分次的剂量。如果每次分次的剂量主要位于急性剂量反应曲线的线性部分，那么反应是线性的，且与低剂量率照射后的反应相似。如果每次分次的剂量处于急性剂量反应曲线二次部分显著的区域，那么肿瘤发生率高于低剂量率照射后的发生率。
