Ekblad U, Erkkola R, Uotila P
Prostaglandins. 1987 Apr;33(4):553-60. doi: 10.1016/0090-6980(87)90278-4.
The release of prostaglandin E2 and F2 alpha, thromboxane B2 and 6-keto-prostaglandin F1 alpha was measured in isolated human placental cotyledons perfused under high- and low-oxygen conditions. Also the effect of reoxygenation on prostaglandin production was studied. During the high-oxygen period, prostaglandin E2 accounted for 44% and 6-keto-prostaglandin F1 alpha for 28% of all prostaglandin release, and the rank order of prostaglandin release was E2 greater than 6-keto-prostaglandin F1 alpha greater than thromboxane B2 greater than prostaglandin F2 alpha. Hypoxia had no significant effect on quantitative prostaglandin release, but the ratio of prostaglandin E2 to prostaglandin F2 alpha was significantly increased. After the hypoxic period during reoxygenation the release of 6-keto-prostaglandin F1 alpha was significantly decreased, as was the ratio of 6-keto-prostaglandin F1 alpha to thromboxane B2. Also the ratio of the vasodilating prostaglandins (E2, 6-keto-prostaglandin F1 alpha) to the vasoconstricting prostaglandins (thromboxane B2, prostaglandin F2 alpha) was decreased during reoxygenation period. With the constant flow rate, the perfusion pressure increased during hypoxia in six and was unchanged in three preparations. The results indicate that changes in the tissue oxygenation in the placenta affect prostaglandin release in the fetal placental circulation. This may also have circulatory consequences.
在高氧和低氧条件下灌注的离体人胎盘小叶中，检测了前列腺素E2、F2α、血栓素B2和6-酮-前列腺素F1α的释放情况。同时研究了复氧对前列腺素产生的影响。在高氧期，前列腺素E2占所有前列腺素释放量的44%，6-酮-前列腺素F1α占28%，前列腺素释放的顺序为E2＞6-酮-前列腺素F1α＞血栓素B2＞前列腺素F2α。缺氧对前列腺素的定量释放无显著影响，但前列腺素E2与前列腺素F2α的比值显著增加。在缺氧期后的复氧过程中，6-酮-前列腺素F1α的释放显著减少，6-酮-前列腺素F1α与血栓素B2的比值也显著降低。此外，在复氧期，血管舒张性前列腺素（E2、6-酮-前列腺素F1α）与血管收缩性前列腺素（血栓素B2、前列腺素F2α）的比值降低。在恒定流速下，6份标本在缺氧时灌注压力升高，3份标本无变化。结果表明，胎盘组织氧合的变化会影响胎儿胎盘循环中前列腺素的释放。这也可能产生循环方面的后果。
