Kimura S, Shitano N, Amasaki C, Taimatsu M, Kanbashi T, Ikeda N
Radioisotopes. 1987 Mar;36(3):108-14. doi: 10.3769/radioisotopes.36.3_108.
The investigations about the radiolysis materials and their quantities, and, anti-microbial activities of gamma-irradiated (in the ranges of 0.516-2.064 kC/kg (2-8 MR] acrinol on liquid dosage form have been carried out to study the application of radiosterilization. About nine components were found as radiolysis materials. Most of them were also found in the UV-irradiated of Fenton's reagent-treated acrinol solution. Increase of anti-microbial activity was observed with gamma-irradiated acrinol solutions, but this phenomenon was not long-lasting. The micro-organism such as Pseudomonas aeruginosa or Staphylococcus aureus that infect at the lips of wound are highly sensitive to the gamma-irradiation. They are almost sterilized by the irradiation of 10 kGy (1.0 Mrad). At a low acrinol concentration, the decomposition rate of acrinol by the irradiation was relatively high. When 1.0% of acrinol solution was irradiated at a dose of 10 kGy (1.0 Mrad), the decomposition of the drug was less than 2% and the variation of anti-microbial activity was negligible.
为研究辐射灭菌的应用，已对辐射分解产物及其数量以及γ射线辐照（剂量范围为0.516 - 2.064 kC/kg（2 - 8 MR））的红汞水溶液的抗菌活性进行了研究。发现约有九种成分是辐射分解产物。其中大多数在经芬顿试剂处理的红汞溶液的紫外线辐照中也能被发现。γ射线辐照的红汞溶液的抗菌活性有所增加，但这种现象并不持久。感染伤口边缘的微生物如铜绿假单胞菌或金黄色葡萄球菌对γ射线高度敏感。它们在10 kGy（1.0 Mrad）的辐照下几乎被灭菌。在红汞浓度较低时，辐照导致的红汞分解速率相对较高。当1.0%的红汞溶液以10 kGy（1.0 Mrad）的剂量辐照时，药物分解小于2%，抗菌活性的变化可忽略不计。
