Philipp M, Marneros A
Pharmakopsychiatr Neuropsychopharmakol. 1978 Sep;11(5):235-40. doi: 10.1055/s-0028-1094583.
An open pilot study on 30 in-patients with endogenous depression showed a clear-cut circadian fluctuation of the therapeutical effect of single doses of lofepramine administered at three different times of the day (8 a.m., and 12 p.m.). A single-dose drug schedule with 210 mg lofepramine at 12 p.m. also proved superior (p less than .05) to the conventional divided-dose drug schedule with 70 mg lofepramine at three times of the day. The chronobiological background and the therapeutical consequences of these findings are discussed.
一项针对30名内源性抑郁症住院患者的开放性试点研究表明，在一天中的三个不同时间（上午8点和中午12点）给予单剂量洛非帕明，其治疗效果呈现出明显的昼夜节律波动。中午12点服用210毫克洛非帕明的单剂量给药方案也被证明优于传统的每日三次每次70毫克洛非帕明的分剂量给药方案（p小于0.05）。本文讨论了这些发现的生物钟学背景及其治疗意义。
