Philipp M, Werner C
Pharmakopsychiatr Neuropsychopharmakol. 1979 Jul;12(4):346-8. doi: 10.1055/s-0028-1094629.
The improvement of depression after partial sleep deprivation in the second half of the night (sd) is tested for its predictory power for the therapeutical efficacy of pharmacotherapy with lofepramine. In a group of 15 patients with depression, we found that in contradiction to the findings of Wirz-Justice and collaborators (1976), the velocity of the antidepressive effect of sd has no predictive value. On the other hand, the amount of depression improvement after sd is of predictive value. This is independent of the time of occurrence of the improvement peak after sd. An improvement of more than 35% measured in the Bf-S or in the H.DRS on the first or the second day after sd is highly predictive for a good response to three weeks of 210 mg lofepramine per day (p = .05).
对下半夜部分睡眠剥夺（sd）后抑郁症状的改善情况进行测试，以检验其对洛非帕明药物治疗疗效的预测能力。在一组15名抑郁症患者中，我们发现，与维尔茨-贾斯蒂斯及其合作者（1976年）的研究结果相反，sd的抗抑郁作用速度没有预测价值。另一方面，sd后抑郁症状改善的程度具有预测价值。这与sd后改善峰值出现的时间无关。在sd后的第一天或第二天，通过Bf-S或H.DRS测量，改善超过35%对每天服用210毫克洛非帕明三周的良好反应具有高度预测性（p = .05）。
