Becker G M, Gandolfi A J, Nagle R B
Res Commun Chem Pathol Pharmacol. 1987 May;56(2):277-80.
Cyclosporin A (CSA), a potent immunosuppressant with the adverse side effect of nephrotoxicity, inhibited cell growth of pig kidney tubule cells (LLC-PK1) in culture. CSA (10(-5) M) also induced intense cytoplasmic vacuolation and the formation of dense granules. At the same concentration an analogue of CSA, cyclosporin G, had much less effect. This cell line may prove useful for revealing the mechanism of CSA-nephrotoxicity and testing the nephrotoxic potential of new analogues of cyclosporine.
环孢素A（CSA）是一种具有肾毒性副作用的强效免疫抑制剂，可抑制培养的猪肾小管细胞（LLC-PK1）的细胞生长。CSA（10^(-5) M）还可诱导强烈的细胞质空泡化并形成致密颗粒。在相同浓度下，CSA的类似物环孢素G的作用要小得多。该细胞系可能有助于揭示CSA肾毒性的机制，并测试环孢素新类似物的肾毒性潜力。
