Nomiyama K, Nomiyama H, Kikuchi T, Yotoriyama M
J UOEH. 1987 Mar 20;9 Suppl:95-110.
Intraperitoneal pretreatment with a large dose of Cd, Zn, Hg, Mn or Ag remarkably depressed the lethal effects of X-ray. The CHX pretreatment before metal challenge depressed the lethal effects of X-ray more remarkably. Therefore, metal-binding protein may not play an important role in protective effects of metal pretreatment on the lethal effects of X-ray, but quantum mechanical characters of metals may do so.
用大剂量的镉、锌、汞、锰或银进行腹腔预处理可显著降低X射线的致死效应。在金属刺激前用环己酰亚胺预处理能更显著地降低X射线的致死效应。因此,金属结合蛋白可能在金属预处理对X射线致死效应的保护作用中不起重要作用,而金属的量子力学特性可能起作用。