Venkatesh Ramesh, Reddy Nikitha Gurram, Mishra Pranjal, Yadav Naresh Kumar, Chhablani Jay
Narayana Nethralaya, #121/C, 1st R Block, Chord Road, Rajaji Nagar, Bengaluru, 560010, Karnataka, India.
Deptartment of Retina and Vitreous, Narayana Nethralaya, #121/C, 1st R Block, Chord Road, Rajaji Nagar, Bengaluru, 560010, Karnataka, India.
Int J Retina Vitreous. 2022 Aug 26;8(1):59. doi: 10.1186/s40942-022-00410-3.
To correlate the structural-vascular-functional changes in type 2 non-proliferative macular telangiectasia (MacTel) using optical coherence tomography (OCT) angiography (OCTA).
In this retrospective study, OCTA and enface OCT image analysis of eyes with confirmed diagnosis of non-proliferative type 2 MacTel was performed. The 'MacTel area' was calculated by marking the outer boundary of an area affected by MacTel on superficial (SCP) and deep capillary plexus (DCP) on OCTA images and photoreceptor layer (PRL) on enface OCT scan. At every follow-up OCTA scan visit, best-corrected visual acuity, MacTel area and stage of disease was documented. Analyses between disease stage, MacTel area and logMAR visual acuity was carried out.
In total, 38 single-visit OCTA scans of 22 patients were included. The mean age was 58.9 ± 10.98 years. An increase in disease severity stage correlated positively with MacTel area in SCP segmentations slab (r = 0.334; p = 0.04) and logMAR visual acuity (r = 0.338; p = 0.038). No correlation in the DCP area or PRL area (p > 0.05) was noted with disease stage. A statistically significant positive correlation was noted between the structural changes in PRL layer with vascular changes in SCP (p = 0.021) but not in DCP (p = 0.199). No correlation of visual acuity with changes in SCP, DCP or PRL was noted (p > 0.05).
OCTA is a useful adjunct for determining disease severity in type 2 non-proliferative MacTel by assessing the structural-vascular changes. Further longitudinal studies need to be considered in future for understanding the pathomechanism of retinal damage in type 2 MacTel.
使用光学相干断层扫描血管造影（OCTA）来关联2型非增殖性黄斑毛细血管扩张症（MacTel）的结构-血管-功能变化。
在这项回顾性研究中，对确诊为非增殖性2型MacTel的眼睛进行了OCTA和表面OCT图像分析。通过在OCTA图像上标记受MacTel影响区域的浅表毛细血管丛（SCP）和深层毛细血管丛（DCP）的外边界以及在表面OCT扫描上标记光感受器层（PRL）来计算“MacTel区域”。在每次随访的OCTA扫描时，记录最佳矫正视力、MacTel区域和疾病阶段。对疾病阶段、MacTel区域和logMAR视力进行分析。
总共纳入了22例患者的38次单次就诊OCTA扫描。平均年龄为58.9±10.98岁。疾病严重程度阶段的增加与SCP分割层板中的MacTel区域呈正相关（r = 0.334；p = 0.04）以及与logMAR视力呈正相关（r = 0.338；p = 0.038）。未发现DCP区域或PRL区域与疾病阶段有相关性（p>0.05）。PRL层的结构变化与SCP中的血管变化之间存在统计学上显著的正相关（p = 0.021），但与DCP中无相关性（p = 0.199）。未发现视力与SCP、DCP或PRL的变化有相关性（p>0.05）。
OCTA通过评估结构-血管变化，是确定2型非增殖性MacTel疾病严重程度的有用辅助手段。未来需要进一步开展纵向研究以了解2型MacTel视网膜损伤的发病机制。
