Mishra Anuradha, Ahsan Rabiya, Islam Anas, Tiwari Rohit Kumar, Dash Pragyandip P
Department of Pharmacology, Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, 226026, Uttar Pradesh, India.
Department of Bioscience, Integral University, Dasauli, Kursi Road, Lucknow, 226026, Uttar Pradesh, India.
Recent Pat Nanotechnol. 2024;18(2):164-178. doi: 10.2174/1872210516666220825170125.
Around 1.5 billion people in the world are affected by complex neurological disorders, and the figure is increasing alarmingly due to unsatisfactory clinical outcomes. To date, no conventional formulation can show a promising effect on the control or prevention of neurodegeneration. However, Nano delivery tools have shown better penetration and profound action on the targeted area of the brain.
Although existing Nano therapeutic approaches are abundant but would not reach the clinic due to their improper bioavailability, BBB restricts its entry and causes improper biodistribution, so it is a challenge to use certain bioactive as a potential therapy in neurodegenerative disorders. Hybrid nanocarriers are nano-vesicular transported systems which could be utilized as carriers for the delivery of both hydrophilic and hydrophobic compounds. Available patents on nanodelivery for therapeutic approaches will also include in this review.
Hybrid Nano delivery system may provide good stability to polar and nonpolar compounds and improve their stability.
This manuscript updates the available findings on the Nano vesicular system to deliver drugs for neurodegenerative disorders.
全球约15亿人受复杂神经系统疾病影响，且由于临床疗效不尽人意，这一数字正以惊人的速度增长。迄今为止，尚无传统制剂能在控制或预防神经退行性变方面显示出有前景的效果。然而，纳米递送工具已显示出在脑靶向区域具有更好的穿透性和显著作用。
尽管现有的纳米治疗方法众多，但由于其生物利用度不佳而无法进入临床，血脑屏障限制其进入并导致生物分布不当，因此将某些生物活性物质用作神经退行性疾病的潜在治疗方法是一项挑战。杂化纳米载体是纳米囊泡运输系统，可作为亲水性和疏水性化合物递送的载体。本综述还将包括治疗方法纳米递送方面的现有专利。
杂化纳米递送系统可为极性和非极性化合物提供良好的稳定性，并提高其稳定性。
本文更新了关于纳米囊泡系统用于递送神经退行性疾病药物的现有研究结果。
