杂交药物研发的最新进展
Recent Advances in the Development of Hybrid Drugs.
作者信息
Morais Tânia S
机构信息
Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
出版信息
Pharmaceutics. 2024 Jul 1;16(7):889. doi: 10.3390/pharmaceutics16070889.
Abstract
In the search for innovative, selective, effective, and safer treatment strategies, hybrid drugs have gained worldwide momentum [...].
摘要
在寻找创新、有选择性、有效且更安全的治疗策略的过程中，杂合药物在全球范围内获得了发展势头[...]。
相似文献
1
Recent Advances in the Development of Hybrid Drugs.杂交药物研发的最新进展
Pharmaceutics. 2024 Jul 1;16(7):889. doi: 10.3390/pharmaceutics16070889.
2
Advances in the development of hybrid anticancer drugs.抗癌药物的联合研发进展。
Expert Opin Drug Discov. 2013 Aug;8(8):1029-47. doi: 10.1517/17460441.2013.798296. Epub 2013 May 7.
3
Review of ultrasound combinations with hybrid and innovative techniques for extraction and processing of food and natural products.超声组合与混合及创新技术在食品和天然产物提取与加工中的应用综述。
Ultrason Sonochem. 2021 Aug;76:105625. doi: 10.1016/j.ultsonch.2021.105625. Epub 2021 Jun 11.
4
Recent Advances in the Delivery Carriers and Chemical Conjugation Strategies for Nucleic Acid Drugs.核酸药物递送载体与化学偶联策略的最新进展
Cancers (Basel). 2021 Aug 1;13(15):3881. doi: 10.3390/cancers13153881.
5
Innovative Opioid Peptides and Biased Agonism: Novel Avenues for More Effective and Safer Analgesics to Treat Chronic Pain.创新型阿片肽和偏向激动剂：用于治疗慢性疼痛的更有效和更安全的镇痛药的新途径。
Curr Med Chem. 2018;25(32):3895-3916. doi: 10.2174/0929867324666170216095233.
6
Clinical implementation of drug metabolizing gene-based therapeutic interventions worldwide.全球范围内基于药物代谢基因的治疗干预措施的临床实施。
Hum Genet. 2022 Jun;141(6):1137-1157. doi: 10.1007/s00439-021-02369-x. Epub 2021 Oct 1.
7
Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors.提高传统抗癌药物作为对抗多药耐药肿瘤的新工具。
Drug Resist Updat. 2020 May;50:100682. doi: 10.1016/j.drup.2020.100682. Epub 2020 Feb 7.
8
[New strategies for the development of antiviral molecules].[抗病毒分子开发的新策略]
Rev Francoph Lab. 2009 Dec;2009(417):91-100. doi: 10.1016/S1773-035X(09)70313-2. Epub 2009 Dec 11.
9
Recent Advances in the Development of Chemotherapeutic Agents for Malaria.抗疟疾化学疗法药物的最新进展。
Mini Rev Med Chem. 2021;21(12):1487-1508. doi: 10.2174/1389557521666201221161750.
10
Utilizing Hybrid Techniques to Maximize Clinical Outcomes in Congenital Heart Disease.利用混合技术优化先天性心脏病的临床治疗效果
Curr Cardiol Rep. 2017 Aug;19(8):72. doi: 10.1007/s11886-017-0878-2.
引用本文的文献
1
Therapeutic Potential of Isoxazole-(Iso)oxazole Hybrids: Three Decades of Research.异恶唑-（异）恶唑杂化物的治疗潜力：三十年研究历程
Int J Mol Sci. 2025 Jul 23;26(15):7082. doi: 10.3390/ijms26157082.
2
Pharmacochemical Studies of Synthesized Coumarin-Isoxazole-Pyridine Hybrids.合成香豆素-异恶唑-吡啶杂化物的药物化学研究
Molecules. 2025 Apr 2;30(7):1592. doi: 10.3390/molecules30071592.
3
Synthesis, cytotoxicity, apoptosis-inducing activity and molecular docking studies of novel isatin-podophyllotoxin hybrids.新型异吲哚酮-鬼臼毒素杂合物的合成、细胞毒性、诱导凋亡活性及分子对接研究
RSC Adv. 2025 Jan 28;15(4):2825-2839. doi: 10.1039/d4ra08691k. eCollection 2025 Jan 23.
4
Synthesis of Novel Benzothiazole-Profen Hybrid Amides as Potential NSAID Candidates.新型苯并噻唑-布洛芬杂合酰胺作为潜在非甾体抗炎药候选物的合成
Molecules. 2024 Dec 30;30(1):107. doi: 10.3390/molecules30010107.
本文引用的文献
1
Exploring the potential of tamoxifen-based copper(ii) dichloride in breast cancer therapy.探索基于他莫昔芬的二氯化铜（II）在乳腺癌治疗中的潜力。
RSC Med Chem. 2023 Sep 12;14(12):2574-2582. doi: 10.1039/d3md00344b. eCollection 2023 Dec 13.
2
Chlorambucil-Bearing Hybrid Molecules in the Development of Potential Anticancer Agents.含氯苯丁酸的杂交分子在潜在抗癌药物研发中的应用。
Molecules. 2023 Sep 30;28(19):6889. doi: 10.3390/molecules28196889.
3
Xanthine-Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.黄嘌呤-多巴胺杂合分子作为具有治疗神经退行性疾病潜力的多靶标药物。
Biomolecules. 2023 Jul 5;13(7):1079. doi: 10.3390/biom13071079.
4
Exploring the Anticancer Activity of Tamoxifen-Based Metal Complexes Targeting Mitochondria.探讨基于他莫昔芬的靶向线粒体的金属配合物的抗癌活性。
J Med Chem. 2023 Jul 27;66(14):9823-9841. doi: 10.1021/acs.jmedchem.3c00617. Epub 2023 Jul 6.
5
Therapeutic significance of molecular hybrids for breast cancer research and treatment.分子杂合体在乳腺癌研究与治疗中的治疗意义。
RSC Med Chem. 2022 Nov 29;14(2):218-238. doi: 10.1039/d2md00356b. eCollection 2023 Feb 22.
6
Hybrid Molecules as Potential Drugs for the Treatment of HIV: Design and Applications.作为治疗艾滋病潜在药物的杂合分子：设计与应用
Pharmaceuticals (Basel). 2022 Aug 31;15(9):1092. doi: 10.3390/ph15091092.
7
Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids.杂合药物的概念及抗癌杂合体的最新进展
Pharmaceuticals (Basel). 2022 Aug 28;15(9):1071. doi: 10.3390/ph15091071.
8
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells.药物外排泵 MDR1 促进了癌细胞对 PROTAC 的固有和获得性耐药。
Sci Signal. 2022 Aug 30;15(749):eabn2707. doi: 10.1126/scisignal.abn2707.
9
Hybrid Nanocarriers for Neurological Disorders: Diagnostic & Therapeutic Approach.用于神经系统疾病的混合纳米载体：诊断与治疗方法
Recent Pat Nanotechnol. 2024;18(2):164-178. doi: 10.2174/1872210516666220825170125.
10
Design and synthesis of hybrid compounds as novel drugs and medicines.作为新型药物的杂化化合物的设计与合成。
RSC Adv. 2022 Jul 6;12(30):19470-19484. doi: 10.1039/d2ra03281c. eCollection 2022 Jun 29.
Zotero 插件