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杂交药物研发的最新进展

Recent Advances in the Development of Hybrid Drugs.

作者信息

Morais Tânia S

机构信息

Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

出版信息

Pharmaceutics. 2024 Jul 1;16(7):889. doi: 10.3390/pharmaceutics16070889.

DOI:10.3390/pharmaceutics16070889
PMID:39065586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11279447/
Abstract

In the search for innovative, selective, effective, and safer treatment strategies, hybrid drugs have gained worldwide momentum [...].

摘要

在寻找创新、有选择性、有效且更安全的治疗策略的过程中，杂合药物在全球范围内获得了发展势头[...]。

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Molecules. 2023 Sep 30;28(19):6889. doi: 10.3390/molecules28196889.
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Xanthine-Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.黄嘌呤-多巴胺杂合分子作为具有治疗神经退行性疾病潜力的多靶标药物。
Biomolecules. 2023 Jul 5;13(7):1079. doi: 10.3390/biom13071079.
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Exploring the Anticancer Activity of Tamoxifen-Based Metal Complexes Targeting Mitochondria.探讨基于他莫昔芬的靶向线粒体的金属配合物的抗癌活性。
J Med Chem. 2023 Jul 27;66(14):9823-9841. doi: 10.1021/acs.jmedchem.3c00617. Epub 2023 Jul 6.
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Therapeutic significance of molecular hybrids for breast cancer research and treatment.分子杂合体在乳腺癌研究与治疗中的治疗意义。
RSC Med Chem. 2022 Nov 29;14(2):218-238. doi: 10.1039/d2md00356b. eCollection 2023 Feb 22.
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Pharmaceuticals (Basel). 2022 Aug 31;15(9):1092. doi: 10.3390/ph15091092.
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