生姜提取物对多发性硬化症大鼠胼胝体脱髓鞘的预防作用。
The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis.
出版信息
Iran Biomed J. 2022 Jul 1;26(4):330-9. doi: 10.52547/ibj.2979.
BACKGROUND
Multiple sclerosis (MS) is the most prevalent neurological disability of young adults. Anti-inflammatory drugs have relative effects on MS. The anti-inflammatory and antioxidative effects of Zingiber officinale (ginger) have been proven in some experimental and clinical investigations. The aim of this study was to evaluate the effects of ginger extract on preventing myelin degradation in a rat model of MS.
METHODS
Forty nine male Wistar rats were used in this study and divided into four control groups: the normal group, cuprizone-induced group, sham group (cuprizone [CPZ] + sodium carboxymethyl cellulose [NaCMC]), standard control group (fingolimod + cuprizone), including three experimental groups of CPZ, each receiving three different doses of ginger extract: 150, 300, and 600mg/kg /kg/day.
RESULTS
Ginger extract of 600 mg/kg prevented corpus callosum from demyelination; however, a significant difference was observed in the fingolimod group (p < 0.05). Difference in the CPZ group was quite significant (p < 0.05).
CONCLUSION
Treatment with ginger inhibited demyelination and alleviated remyelination of corpus callosum in rats. Therefore, it could serve as a therapeutic agent in the MS.
背景
多发性硬化症（MS）是最常见的青年期神经系统残疾。抗炎药物对 MS 有相对的疗效。生姜（ginger）具有抗炎和抗氧化作用，在一些实验和临床研究中得到了证实。本研究旨在评估生姜提取物对 MS 大鼠髓鞘降解的预防作用。
方法
本研究使用了 49 只雄性 Wistar 大鼠，分为 4 个对照组：正常组、铜缺乏诱导组、假手术组（CPZ+羧甲基纤维素钠）、标准对照组（fingolimod+CPZ），包括 3 个 CPZ 实验组，分别给予生姜提取物 150、300 和 600mg/kg/d。
结果
600mg/kg 的生姜提取物可预防胼胝体脱髓鞘；然而，与 fingolimod 组相比差异显著（p<0.05）。CPZ 组的差异也非常显著（p<0.05）。
结论
生姜提取物抑制脱髓鞘，并减轻大鼠胼胝体的髓鞘再形成。因此，它可以作为 MS 的治疗药物。
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