Zhao Chengye, Qian Xunjia, Qin Minni, Sun Xinyang, Yu Qingqing, Liu Jianyu, Zhu Qing, Wang Andong
School of Pharmacy, Nantong University, Nantong, China.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
J Pharm Pharmacol. 2023 Jan 31;75(1):33-48. doi: 10.1093/jpp/rgac064.
The conducted search reveals that Juglans mandshurica Maximowicz, called Manchuria walnuts, had many local uses that can be categorized into cancer, dermatosis and acesodyne.
Various metabolites including diarylheptanoids, naphthoquinones, and flavonoids (also their glycosides) were reported as bioactive metabolites. The isolated metabolites and extracts from J. mandshurica showed different biological activity including cytotoxicity, anti-inflammation, antimelanotic, anticomplement, anti-HIV, antimicrobial and anti-obesity activity.
It is indicated that this review will add value to more scientific research on J. mandshurica and enhance the increased interest in the sustainable commercialization of J. mandshurica. It also leads to the validation of unverified ethnobotanical claims. Future studies on J. mandshurica would be focused to establish the links between the pharmacological activity, bioactive metabolites, and traditional uses.
所进行的检索表明，胡桃楸（Juglans mandshurica Maximowicz），又称满洲核桃，在当地有多种用途，可分为癌症、皮肤病和止痛方面。
据报道，包括二芳基庚烷类、萘醌类和黄酮类（及其糖苷）在内的各种代谢产物为生物活性代谢产物。从胡桃楸中分离出的代谢产物和提取物表现出不同的生物活性，包括细胞毒性、抗炎、抗黑色素生成、抗补体、抗艾滋病毒、抗菌和抗肥胖活性。
表明本综述将为对胡桃楸的更多科学研究增添价值，并增强对胡桃楸可持续商业化日益增长的兴趣。它还导致对未经证实的民族植物学主张的验证。未来对胡桃楸的研究将集中于建立药理活性、生物活性代谢产物和传统用途之间的联系。
