Isacson J, Allander E, Broström L A
Scand J Rheumatol. 1987;16(3):145-52. doi: 10.3109/03009748709165267.
A population survey was carried out in Stockholm during the period 1965-67 for the purpose of determining the prevalence of rheumatoid arthritis (RA). 239 subjects with RA were found in a random sample of 15,268. In 1983, 17 years later, all the 127 persons still living could be traced, 109 of whom were re-examined. In 95, all the information required to satisfy the New York diagnostic criteria was available, i.e. with radiographs of the hands and feet and a Waaler-Rose test. The number of subjects with involvement of at least 3 joints (criterion No. 2) had decreased from 72 to 36, while the persons with a positive Waaler-Rose test (criterion No. 3) had increased from 9 to 18. The total number of fulfilled criteria showed a reduction from a median of 2 criteria to 1. The Steinbrocker functional class remained unchanged for the group as a whole (median Class 2), with a significant deterioration only in the oldest age-group (from 2 to 3). The knee was most often the single joint in which the disease had started and also the joint which caused the subjects the most inconvenience at the follow-up. Medical records were traced for 85 of the 112 who had died. Among them, 44 cases of RA or polyarthritis were noted. The present study gives a conception of RA in the population, as well as of its development over a long span of time.
1965年至1967年期间,在斯德哥尔摩进行了一项人口调查,目的是确定类风湿性关节炎(RA)的患病率。在15268人的随机样本中发现了239名患有RA的受试者。17年后的1983年,仍在世的127人全部可以找到,其中109人接受了重新检查。在95人中,获得了满足纽约诊断标准所需的所有信息,即手部和足部的X光片以及瓦勒-罗斯试验。至少累及3个关节的受试者数量(标准2)从72人减少到36人,而瓦勒-罗斯试验呈阳性的人数(标准3)从9人增加到18人。满足标准的总数从中位数2项减少到1项。斯坦布鲁克功能分级在整个组中保持不变(中位数为2级),仅在最年长的年龄组中有显著恶化(从2级降至3级)。膝关节最常是疾病开始的单个关节,也是随访中给受试者带来最大不便的关节。在112名已死亡的受试者中,有85人的病历被追查。其中,记录了44例RA或多关节炎病例。本研究给出了人群中RA的情况以及其在很长一段时间内的发展情况。