Isacson J, Broström L A, Allander E, Czechowskij J
Scand J Rheumatol. 1987;16(3):153-9. doi: 10.3109/03009748709165268.
In 1967 a population survey of rheumatoid arthritis (RA) was carried out in Stockholm. In a sample of 15,268 subjects, 239 were found to have RA. In 1983, i.e. 17 years later, all the 127 subjects still living could be traced, 109 of them were re-examined and 98 radiographed. Whole-leg weight-bearing radiographs of the 168 knee joints were available for determination of the HKA (Hip-knee-ankle) angle and of the articular space. In this sample, which represented the epidemiological spectrum of RA, disease activity could be associated with radiologic changes in the knee joint, e.g., erosions, cysts and sclerosis. These radiologic findings were predictable owing to the fact that New York criterion no. 3 or 4 for RA had been fulfilled 17 years earlier. In 52% of those with active RA at the follow-up, the articular space was seen to be narrowed. A certain varus angulation (2.2 degrees) was ascertained in the joints of subjects with inactive RA, while this angulation was less pronounced (0.7 degrees) in knee joints of subjects with an active disease.
1967年,在斯德哥尔摩开展了一项类风湿性关节炎(RA)的人口调查。在15268名受试者的样本中,发现239人患有RA。1983年,即17年后,所有在世的127名受试者都能被找到,其中109人接受了重新检查,98人进行了X光检查。168个膝关节的全腿负重X光片可用于测定髋-膝-踝(HKA)角和关节间隙。在这个代表RA流行病学范围的样本中,疾病活动可能与膝关节的放射学变化有关,例如侵蚀、囊肿和硬化。由于17年前就已符合纽约RA标准第3条或第4条,这些放射学表现是可预测的。在随访中有活动期RA的患者中,52%可见关节间隙变窄。在无活动期RA的受试者关节中确定存在一定的内翻角度(2.2度),而在有活动期疾病的受试者膝关节中,这种角度不那么明显(0.7度)。