Department of Hematology Oncology, Tai'an Medical District, 960 Hospital of the joint logistics support force of the Chinese people's Liberation Army.
Department of general surgery, Tai'an Medical District, 960 Hospital of the joint logistics support force of the Chinese people's Liberation Army.
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):146-152. doi: 10.14715/cmb/2022.68.5.20.
Colony-stimulating factors (CSFs) are glycoproteins that stimulate the proliferation and differentiation of hematopoietic progenitor cells in the bone marrow. But numerous studies have shown that these factors can stimulate the proliferation of non-hematopoietic cells, including cancer cells. Hence, in this study, Macrophage-CSF (M-CSF), macrophage-granulocyte CSF (GM-CSF), and granulocyte-SCF (G-CSF) were evaluated in the serum of patients with breast tumors and their relationship with pathological and paraclinical parameters of the disease. In this study, 62 patients with breast cancer who had not received any treatment and 54 healthy women who matched the age group with the patient group were included as a control group. After obtaining informed consent, 5ml of peripheral blood was taken from both groups, and their serum was isolated. Serum levels of the studied cytokines were measured by the cytokine-bead array method. Data were analyzed using SPSS18 software and a significance level of 0.05. The mean serum levels of M-CSF, G-CSF, and GM-CSF growth factors in patients with breast cancer were 63.48, 16.13, and 6.11pg/ml, respectively. Although the statistical analysis did not show a significant difference between serum levels of these growth factors in the patient and control groups (p <0.05), further studies showed that with increasing disease stages from I to III, serum levels of GM-CSF significantly. Decreases (p = 0.016). Overall, the results of this study indicated the antitumor role of GM-CSF in breast cancer. However, confirmation of these results requires more complete studies with larger sample sizes.
集落刺激因子（CSFs）是刺激骨髓中造血祖细胞增殖和分化的糖蛋白。但许多研究表明，这些因子可以刺激非造血细胞的增殖，包括癌细胞。因此，在这项研究中，评估了巨噬细胞集落刺激因子（M-CSF）、巨噬细胞-粒细胞集落刺激因子（GM-CSF）和粒细胞集落刺激因子（G-CSF）在乳腺癌患者血清中的表达，并探讨其与疾病的病理和临床参数的关系。
在这项研究中，纳入了 62 例未经任何治疗的乳腺癌患者和 54 例年龄与患者组匹配的健康女性作为对照组。在获得知情同意后，从两组中抽取 5ml 外周血，并分离血清。采用细胞因子微珠阵列法检测研究细胞因子的血清水平。数据采用 SPSS18 软件进行分析，显著性水平为 0.05。乳腺癌患者血清中 M-CSF、G-CSF 和 GM-CSF 生长因子的平均水平分别为 63.48、16.13 和 6.11pg/ml。虽然统计分析显示患者组和对照组血清中这些生长因子的水平没有显著差异（p＜0.05），但进一步的研究表明，随着疾病从 I 期到 III 期的进展，GM-CSF 的血清水平显著降低（p=0.016）。
总的来说，这项研究的结果表明 GM-CSF 在乳腺癌中具有抗肿瘤作用。然而，要证实这些结果，还需要进行更多、更大样本量的研究。
