Department of Neurology, Affiliated Hospital of Xuzhou Medical University, China.
Department of Neurology, Xuzhou First People's Hospital. China.
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):89-95. doi: 10.14715/cmb/2022.68.5.12.
Stroke is the most common, deadly, and complicating neurological disease. Many studies have shown that the levels of some acute inflammatory reactants in people with ischemic stroke are higher than average. Therefore, in this study, three acute inflammatory reactants, i.e., C-reactive protein, Serum cystatin C, and carbohydrate antigen 125, were evaluated in patients with acute ischemic stroke to consider the association between these serums with intra and extra-cerebral vessels stenosis. In this cross-sectional study, 90 patients with non-embolic ischemic stroke were evaluated. The diagnosis was by physical examination, rejection of emboli, and brain imaging. Blood samples were taken in the first 24 hours of a stroke. ELISA test was used to measure CRP, Serum cystatin C, and CA125. Doppler ultrasound of cerebral arteries was also performed in the first five days. Independent chi-square and t-tests were used to analyze the data. The result of CRP level in patients with stenosis was 7.58±1.33μg/ml and in patients without stenosis was 4.10±1.75μg/ml (p = 0.004). Also, there was a significant relationship between serum CRP level and stenosis (p = 0.003). In patients with abnormal CRP, the internal carotid artery, middle cerebral artery, and anterior cerebral artery were the most involved. In patients with normal CRP, the most involved arteries were the anterior cerebral artery, internal carotid artery, and middle cerebral artery, respectively. There was a significant relationship between serum CRP level and the location of internal carotid artery stenosis (p = 0.015) and middle cerebral artery (p = 0.006). The amount of cystatin C between the normal CRP and abnormal CRP groups was statistically significant so that its concentration in the normal group was less than in the abnormal group (p = 0.04). The results of measuring the serum concentration of carbohydrate antigen 125 showed that the serum level in the normal group was statistically lower than in the abnormal group (P = 0.02). The results showed that stenosis of the internal carotid artery and middle cerebral artery is more common in patients with ischemic stroke with high serum CRP levels. This finding suggests that abnormal CRP may be more associated with narrowing some cerebral arteries.
中风是最常见、最致命和最复杂的神经疾病。许多研究表明，缺血性中风患者的一些急性炎症反应物水平高于平均水平。因此，在这项研究中，评估了三种急性炎症反应物，即 C 反应蛋白、血清胱抑素 C 和碳水化合物抗原 125，在急性缺血性中风患者中，以考虑这些血清与颅内和颅外血管狭窄之间的关系。在这项横断面研究中，评估了 90 名非栓塞性缺血性中风患者。通过体格检查、排除栓子和脑部成像来诊断。中风后 24 小时内采集血样。使用 ELISA 试验测量 CRP、血清胱抑素 C 和 CA125。在中风后的头 5 天还进行了大脑动脉多普勒超声检查。使用独立的卡方检验和 t 检验分析数据。狭窄患者的 CRP 水平为 7.58±1.33μg/ml，无狭窄患者为 4.10±1.75μg/ml（p=0.004）。此外，血清 CRP 水平与狭窄之间存在显著关系（p=0.003）。在 CRP 异常的患者中，颈内动脉、大脑中动脉和大脑前动脉最常受累。在 CRP 正常的患者中，最常受累的动脉分别是大脑前动脉、颈内动脉和大脑中动脉。血清 CRP 水平与颈内动脉狭窄（p=0.015）和大脑中动脉狭窄（p=0.006）的位置之间存在显著关系。正常 CRP 和异常 CRP 组之间的胱抑素 C 量有统计学意义，因此正常组的浓度低于异常组（p=0.04）。测量血清碳水化合物抗原 125 浓度的结果表明，正常组的血清水平明显低于异常组（P=0.02）。结果表明，血清 CRP 水平升高的缺血性中风患者颈内动脉和大脑中动脉狭窄更为常见。这一发现表明，异常 CRP 可能与一些大脑动脉狭窄更为相关。
