Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, 510630, China; Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, 510630, China.
Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, 510630, China; Department of Radiology, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.
J Psychiatr Res. 2022 Nov;155:153-162. doi: 10.1016/j.jpsychires.2022.08.010. Epub 2022 Aug 18.
Numerous resting-state functional and structural studies have revealed that many brain regions are involved in the pathogenesis of posttraumatic stress disorder (PTSD), but their findings have been inconsistent. Moreover, there has no study explored the functional and structural alterations across languages in PTSD.
A meta-analysis of whole-brain on the amplitude of low-frequency fluctuation (ALFF) and voxel-based morphometry (VBM) studies that explored alterations in the spontaneous functional brain activity and grey matter volume (GMV) in PTSD patients across languages by using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software.
A total of 15 studies (19 datasets) comprising 577 PTSD patients and 499 HCs for ALFF, and 27 studies (31 datasets) comprising 539 PTSD patients and 693 HCs for VBM were included. Overall, PTSD patients across languages displayed decreased ALFF in the in the left amygdala. For VBM meta-analysis, PTSD patients across languages displayed reduced GMV in the bilateral anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC), striatum, insula, superior temporal gyrus, left postcentral gyrus, and occipital gyrus.
The multimodal meta-analysis suggest that PTSD patients showed similar pattern of aberrant resting-state functional brain activity and structure mainly in the amygdala, suggesting that structural deficits might underlie alterations in function. In addition, some regions exhibited only structural abnormalities in PTSD, including the ACC/mPFC, striatum, insula, primary visual, auditory and sensorimotor cortices. Moreover, consistent alterations in PTSD patients across languages may draw attention to the disparity in multi-cultural considerations in psychiatric research and further understanding the neurophysiopathology of PTSD.
大量的静息态功能和结构研究表明，许多脑区参与了创伤后应激障碍（PTSD）的发病机制，但研究结果并不一致。此外，尚无研究探讨 PTSD 患者跨语言的功能和结构改变。
使用基于种子的随机构象置换分析软件（SDM-PSI），对探讨 PTSD 患者跨语言自发脑功能活动和灰质体积（GMV）改变的全脑低频振幅（ALFF）和基于体素的形态测量学（VBM）研究进行元分析。
共纳入 15 项研究（19 个数据集），包括 577 例 PTSD 患者和 499 例健康对照者的 ALFF 研究，以及 27 项研究（31 个数据集），包括 539 例 PTSD 患者和 693 例健康对照者的 VBM 研究。总体而言，跨语言的 PTSD 患者在左侧杏仁核的 ALFF 降低。对于 VBM 元分析，跨语言的 PTSD 患者双侧前扣带回皮层/内侧前额叶皮质（ACC/mPFC）、纹状体、岛叶、颞上回、左侧中央后回和枕叶的 GMV 减少。
多模态元分析表明，PTSD 患者的静息态功能脑活动和结构存在相似的异常模式，主要在杏仁核，提示结构缺陷可能是功能改变的基础。此外，一些区域仅在 PTSD 中表现出结构异常，包括 ACC/mPFC、纹状体、岛叶、初级视、听和感觉运动皮质。此外，跨语言 PTSD 患者的一致改变可能引起人们对精神科研究中多文化考虑差异的关注，并进一步理解 PTSD 的神经生理病理学。
