Chen Guanmao, Wang Junjing, Gong Jiaying, Qi Zhangzhang, Fu Siying, Tang Guixian, Chen Pan, Huang Li, Wang Ying
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, 510630, China.
Psychol Med. 2022 Oct;52(14):2861-2873. doi: 10.1017/S0033291722002392. Epub 2022 Sep 12.
Numerous studies of resting-state functional imaging and voxel-based morphometry (VBM) have revealed differences in specific brain regions of patients with bipolar disorder (BD), but the results have been inconsistent.
A whole-brain voxel-wise meta-analysis was conducted on resting-state functional imaging and VBM studies that compared differences between patients with BD and healthy controls using Seed-based Mapping with Permutation of Subject Images software.
A systematic literature search identified 51 functional imaging studies (1842 BD and 2190 controls) and 83 VBM studies (2790 BD and 3690 controls). Overall, patients with BD displayed increased resting-state functional activity in the left middle frontal gyrus, right inferior frontal gyrus (IFG) extending to the right insula, right superior frontal gyrus and bilateral striatum, as well as decreased resting-state functional activity in the left middle temporal gyrus extending to the left superior temporal gyrus and post-central gyrus, left cerebellum, and bilateral precuneus. The meta-analysis of VBM showed that patients with BD displayed decreased VBM in the right IFG extending to the right insula, temporal pole and superior temporal gyrus, left superior temporal gyrus extending to the left insula, temporal pole, and IFG, anterior cingulate cortex, left superior frontal gyrus (medial prefrontal cortex), left thalamus, and right fusiform gyrus.
The multimodal meta-analyses suggested that BD showed similar patterns of aberrant brain activity and structure in the insula extending to the temporal cortex, fronto-striatal-thalamic, and default-mode network regions, which provide useful insights for understanding the underlying pathophysiology of BD.
众多关于静息态功能成像和基于体素的形态学测量（VBM）的研究揭示了双相情感障碍（BD）患者特定脑区的差异，但结果并不一致。
使用基于种子点映射的被试图像置换软件，对静息态功能成像和VBM研究进行全脑体素水平的荟萃分析，比较BD患者与健康对照之间的差异。
系统的文献检索确定了51项功能成像研究（1842例BD患者和2190例对照）和83项VBM研究（2790例BD患者和3690例对照）。总体而言，BD患者在左侧额中回、延伸至右侧脑岛的右侧额下回（IFG）、右侧额上回和双侧纹状体的静息态功能活动增加，而在延伸至左侧颞上回和中央后回、左侧小脑以及双侧楔前叶的左侧颞中回的静息态功能活动减少。VBM的荟萃分析显示，BD患者在延伸至右侧脑岛、颞极和颞上回的右侧IFG、延伸至左侧脑岛、颞极和IFG的左侧颞上回、前扣带回皮质、左侧额上回（内侧前额叶皮质）、左侧丘脑和右侧梭状回的VBM降低。
多模态荟萃分析表明，BD在延伸至颞叶皮质的脑岛、额-纹状体-丘脑和默认模式网络区域表现出类似的异常脑活动和结构模式，这为理解BD的潜在病理生理学提供了有用的见解。
