Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Haidian District, Beijing 100191, People's Republic of China; Beijing's Key Laboratory of Food Safety Toxicology Research and Evaluation, Beijing 100191, People's Republic of China.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, People's Republic of China.
Food Chem. 2023 Jan 15;399:133993. doi: 10.1016/j.foodchem.2022.133993. Epub 2022 Aug 23.
At present, uncovering how to preventandcontrol hyperuricemia has become an important public health issue. Fermented traditionalChinesemedicine has exhibited promising applications in the clinical management of hyperuricemia. In this study, we generated a hyperuricemic mouse model to explore the potent therapeutic ability of Bacillus subtilis-fermented Astragalus membranaceus (BFA) on this condition by multi-omics analysis. We found that the serum uric acid level was decreased in hyperuricemic mice after BFA treatment. BFA effectively attenuated renal inflammation and regulated the expression of urate transporters. Additionally, we found that BFA could increase the abundances of butyrate-producing bacteria, including Butyricimonas synergistica, Odoribacter splanchnicus, and Collinsella tanakaei, and probiotics, including Lactobacillus intestinalis and Bacillus mycoides, in hyperuricemic mice. Therefore, we believe that BFA has the potential to become a novel safe and valid functional food for addressing hyperuricemia.
目前，揭示如何预防和控制高尿酸血症已成为一个重要的公共卫生问题。发酵中药在高尿酸血症的临床治疗中表现出了广阔的应用前景。在这项研究中，我们构建了高尿酸血症小鼠模型，通过多组学分析来探究枯草芽孢杆菌发酵黄芪（BFA）对此疾病的强大治疗能力。我们发现，BFA 处理后高尿酸血症小鼠的血清尿酸水平降低。BFA 可有效减轻肾脏炎症并调节尿酸转运蛋白的表达。此外，我们发现 BFA 可增加丁酸产生菌的丰度，包括协同丁酸单胞菌、内脏欧陆森菌和坦纳氏柯林斯菌，以及益生菌，包括肠道乳杆菌和类芽孢杆菌，在高尿酸血症小鼠中。因此，我们认为 BFA 有可能成为一种新型安全有效的功能性食品，用于治疗高尿酸血症。
