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MOGAD-ON 和 AQP4-ON 患者的视网膜结构和微血管特征的差异。

The difference of the retinal structural and microvascular characteristics in patients with MOGAD-ON and AQP4-ON.

机构信息

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.

Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.

出版信息

BMC Neurol. 2022 Aug 27;22(1):323. doi: 10.1186/s12883-022-02848-2.

DOI:10.1186/s12883-022-02848-2
PMID:36030231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9419345/
Abstract

BACKGROUND

Antibodies against myelin-oligodendrocyte-glycoprotein (MOG-Abs) associated disease (MOGAD) has been recognized as a disease entity. Optic neuritis (ON) is the most common symptom in MOGAD. To demonstrate the differences in retinal microvascular characteristics between patients with MOGAD-ON and aquaporin-4 antibody (AQP4-Ab) positive ON.

METHODS

In a prospective study, optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) were used to measure retinal and microvascular parameters.

RESULTS

Twenty-six MOGAD-ON eyes, 40 AQP4-ON eyes, and 60 control eyes were included in the study. The thickness of RNFL and GCC in MOGAD-ON eyes was significantly lower than that of HC (p < 0.001, respectively), but comparable to AQP4-ON eyes. The vessel density in retina capillary plexus (RCP) was reduced significantly in MOGAD-ON than that in AQP4-ON (p < 0.05, respectively). The visual accuracy was positively correlated with vessel density of superficial RCP in MOG-ON (p = 0.001) and positively correlated with the thickness of the inner retina layer in AQP4-ON (p < 0.001).

CONCLUSION

The retinal neuro-axonal damages between MOGAD-ON and AQP4-ON were comparable. Unlike AQP4-ON eyes, microvascular densities were significantly reduced in MOGAD-ON and were positively correlated with the deterioration of visual acuity in MOGAD-ON.

TRIAL REGISTRATION

Clinical and Imaging Patterns of Neuroinflammation Diseases in China (CLUE, NCT: 04106830).

摘要

背景

髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病（MOGAD）已被确认为一种疾病实体。视神经炎（ON）是 MOGAD 最常见的症状。本研究旨在比较 MOGAD-ON 和水通道蛋白 4 抗体（AQP4-Ab）阳性 ON 患者视网膜微血管特征的差异。

方法

前瞻性研究中，采用光学相干断层扫描（OCT）和光学相干断层扫描血管造影（OCTA）测量视网膜和微血管参数。

结果

本研究纳入 26 例 MOGAD-ON 眼、40 例 AQP4-ON 眼和 60 例对照眼。MOGAD-ON 眼的 RNFL 和 GCC 厚度明显低于 HC（分别为 p<0.001），但与 AQP4-ON 眼相当。MOGAD-ON 眼视网膜毛细血管丛（RCP）的血管密度明显低于 AQP4-ON 眼（分别为 p<0.05）。MOG-ON 眼的视敏度与浅层 RCP 的血管密度呈正相关（p=0.001），与 AQP4-ON 眼的内视网膜层厚度呈正相关（p<0.001）。

结论

MOGAD-ON 和 AQP4-ON 之间的视网膜神经轴突损伤相当。与 AQP4-ON 眼不同，MOGAD-ON 眼的微血管密度明显降低，与 MOGAD-ON 眼视敏度的恶化呈正相关。

临床试验注册号

中国神经炎症性疾病的临床和影像学模式（CLUE，NCT：04106830）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d9/9419345/9b384270463d/12883_2022_2848_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d9/9419345/9b384270463d/12883_2022_2848_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d9/9419345/9b384270463d/12883_2022_2848_Fig1_HTML.jpg

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Alterations in the Retinal Vascular Network and Structure in MOG Antibody-Associated Disease: An Optical Coherence Tomography Angiography Study.MOG 抗体相关性疾病的视网膜血管网络和结构改变：光学相干断层血管造影研究。
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