Ford-Hutchinson A W, Walker J R, Davidson E M, Smith M J
Prostaglandins. 1978 Aug;16(2):253-8. doi: 10.1016/0090-6980(78)90027-8.
PGI2, but not its metabolite 6oxoPGF1alpha, is equivalent in potency to PGE1 as a potentiator of carrageenan, histamine and bradykinin-induced rat paw oedemas. PGI2 must, therefore, be considered as a potential mediator of inflammatory processes.
前列环素(PGI2),而非其代谢产物6-氧代前列腺素F1α(6-oxoPGF1α),作为角叉菜胶、组胺和缓激肽诱导的大鼠足爪水肿的增强剂,其效力与前列腺素E1(PGE1)相当。因此,PGI2必须被视为炎症过程的潜在介质。