Higgs E A, Moncada S, Vane J R
Prostaglandins. 1978 Aug;16(2):153-62. doi: 10.1016/0090-6980(78)90018-7.
In the rat paw prostacyclin was 5--10 times less potent than PGE2 in causing oedema, and 5 times less potent in potentiating carrageenin-induced oedema, which it did in a dose-related manner. Prostacyclin was 5 times more potent than PGE2 in producing hyperalgesia and as potent as PGE2 in restoring carrageenin-induced hyperalgesia. The effects on oedema were longer lasting than those on hyperalgesia. 6-oxo-PGF1alpha was 500 times less potent than PGE2 in causing oedema by itself and in potentiating carrageenin-induced oedema. It had no hyperalgesic activity in this test.
在大鼠爪部，前列环素引起水肿的效力比前列腺素E2低5至10倍，在增强角叉菜胶诱导的水肿方面效力低5倍，且呈剂量相关方式。前列环素产生痛觉过敏的效力比前列腺素E2高5倍，在恢复角叉菜胶诱导的痛觉过敏方面与前列腺素E2效力相当。其对水肿的作用比对痛觉过敏的作用持续时间更长。6-氧代前列腺素F1α自身引起水肿以及增强角叉菜胶诱导的水肿的效力比前列腺素E2低500倍。在该试验中它没有痛觉过敏活性。
