Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Department of Neurology, Yale University, New Haven, Connecticut, USA.
Ann Clin Transl Neurol. 2022 Sep;9(9):1475-1480. doi: 10.1002/acn3.51637. Epub 2022 Aug 27.
This retrospective case-controlled study was performed to evaluate whether Epileptiform Activity, suspected clinical seizures, and/or 2HELPS2B/S after nontraumatic Intraparenchymal Hemorrhage or Subarachnoid Hemorrhage can predict Epilepsy. Hundred and thirty-two patients were included-29 (Epilepsy), 103 (Control Group). After matching, the average effect for all three risk factors was significant as follows: (1) Epileptiform Activity (p = 0.012, odds ratio 3.14), (2) suspected seizures (p = 0.021, odds ratio 3.78), and (3) 2HELPS2B/S score (p < 0.001, odds ratio 4.94). This study shows that Epileptiform Activity, suspected seizures, and particularly, the 2HELPS2B/S score in the acute phase are risk factors for the development of epilepsy after nontraumatic intraparenchymal and subarachnoid hemorrhage.
这项回顾性病例对照研究旨在评估非创伤性脑实质出血或蛛网膜下腔出血后是否出现癫痫样活动、疑似临床发作和/或 2HELPS2B/S 能预测癫痫。共纳入 132 例患者-29 例（癫痫组），103 例（对照组）。匹配后，所有三个危险因素的平均效应均有显著意义：（1）癫痫样活动（p=0.012，优势比 3.14），（2）疑似发作（p=0.021，优势比 3.78），（3）2HELPS2B/S 评分（p<0.001，优势比 4.94）。本研究表明，癫痫样活动、疑似发作，尤其是急性期的 2HELPS2B/S 评分是非创伤性脑实质和蛛网膜下腔出血后癫痫发生的危险因素。
