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Infants Receiving Very Early Antiretroviral Therapy Have High CD4 Counts in the First Year of Life.婴儿在生命的第一年接受早期抗逆转录病毒治疗，其 CD4 计数会很高。
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2
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Pharmacokinetics and safety of early nevirapine-based antiretroviral therapy for neonates at high risk for perinatal HIV infection: a phase 1/2 proof of concept study.早期基于奈韦拉平的抗逆转录病毒疗法在围生期 HIV 感染高危新生儿中的药代动力学和安全性：一项 1/2 期概念验证研究。
Lancet HIV. 2021 Mar;8(3):e149-e157. doi: 10.1016/S2352-3018(20)30274-5. Epub 2020 Nov 23.
2
Temporal Trends in Co-trimoxazole Use Among Children on Antiretroviral Therapy and the Impact of Co-trimoxazole on Mortality Rates in Children Without Severe Immunodeficiency.抗逆转录病毒疗法治疗儿童中复方新诺明的使用时间趋势，以及复方新诺明对无严重免疫缺陷儿童死亡率的影响。
J Pediatric Infect Dis Soc. 2019 Nov 6;8(5):450-460. doi: 10.1093/jpids/piy087.
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Tuberculosis incidence is high in HIV-infected African children but is reduced by co-trimoxazole and time on antiretroviral therapy.在感染艾滋病毒的非洲儿童中，结核病发病率很高，但复方新诺明和接受抗逆转录病毒治疗的时长可降低发病率。
BMC Med. 2016 Mar 23;14:50. doi: 10.1186/s12916-016-0593-7.
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Trends in opportunistic infections in the pre- and post-highly active antiretroviral therapy eras among HIV-infected children in the Perinatal AIDS Collaborative Transmission Study, 1986-2004.1986 - 2004年围产期艾滋病协作传播研究中，HIV感染儿童在高效抗逆转录病毒治疗时代前后的机会性感染趋势
Pediatrics. 2007 Jul;120(1):100-9. doi: 10.1542/peds.2006-2052.
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Incidence of opportunistic and other infections in HIV-infected children in the HAART era.高效抗逆转录病毒治疗（HAART）时代HIV感染儿童中机会性感染及其他感染的发病率
JAMA. 2006 Jul 19;296(3):292-300. doi: 10.1001/jama.296.3.292.
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Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-1-infected children and adolescents.基于蛋白酶抑制剂的联合疗法对HIV-1感染儿童和青少年CD4 T细胞恢复的长期影响。
Lancet. 2003 Dec 20;362(9401):2045-51. doi: 10.1016/s0140-6736(03)15098-2.
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Age-related immune reconstitution during highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children.1型人类免疫缺陷病毒感染儿童在高效抗逆转录病毒治疗期间与年龄相关的免疫重建
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Immune repopulation after HAART in previously untreated HIV-1-infected children. Paediatric European Network for Treatment of AIDS (PENTA) Steering Committee.先前未经治疗的HIV-1感染儿童接受高效抗逆转录病毒治疗（HAART）后的免疫重建。欧洲儿科艾滋病治疗网络（PENTA）指导委员会。
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Prophylaxis against Pneumocystis carinii pneumonia among children with perinatally acquired human immunodeficiency virus infection in the United States. Pneumocystis carinii Pneumonia Prophylaxis Evaluation Working Group.美国围产期获得性人类免疫缺陷病毒感染儿童中卡氏肺孢子虫肺炎的预防。卡氏肺孢子虫肺炎预防评估工作组。
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1995 revised guidelines for prophylaxis against Pneumocystis carinii pneumonia for children infected with or perinatally exposed to human immunodeficiency virus. National Pediatric and Family HIV Resource Center and National Center for Infectious Diseases, Centers for Disease Control and Prevention.1995年修订的针对感染人类免疫缺陷病毒或在围产期接触过该病毒的儿童预防卡氏肺孢子虫肺炎的指南。国家儿科和家庭艾滋病毒资源中心以及疾病控制和预防中心国家传染病中心
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婴儿在生命的第一年接受早期抗逆转录病毒治疗，其 CD4 计数会很高。

Infants Receiving Very Early Antiretroviral Therapy Have High CD4 Counts in the First Year of Life.

机构信息

Center for Biostatistics in AIDS Research in the Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

Clin Infect Dis. 2023 Feb 8;76(3):e744-e747. doi: 10.1093/cid/ciac695.

DOI:10.1093/cid/ciac695
PMID:36031390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10169385/
Abstract

UNLABELLED

We followed 54 infants with in utero HIV after initiating very early antiretroviral treatment. At weeks 24 and 48, ≥80% had CD4 ≥1500 cells/mm3 and CD4% ≥25%. Routine Pneumocystis jirovecii pneumonia prophylaxis in the first year of life may not be necessary for all very early treated infants.

CLINICAL TRIALS REGISTRATION

NCT02140255.

摘要

未加标签

我们对 54 名在子宫内感染 HIV 的婴儿进行了研究，这些婴儿在非常早期就开始接受抗逆转录病毒治疗。在第 24 和 48 周时，≥80%的婴儿的 CD4 细胞≥1500 个/立方毫米，CD4%≥25%。对于所有非常早期接受治疗的婴儿，在生命的第一年可能不需要常规预防卡氏肺孢子虫肺炎。

临床试验注册

NCT02140255。