用于胃肠内镜检查的新型镇静和镇痛药物。
New sedatives and analgesic drugs for gastrointestinal endoscopic procedures.
作者信息
Lee Jae Min, Park Yehyun, Park Jin Myung, Park Hong Jun, Bae Jun Yong, Seo Seung Young, Lee Jee Hyun, Chon Hyung Ku, Chung Jun-Won, Choi Hyun Ho, Lee Jun Kyu, Kim Byung-Wook
机构信息
Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea.
Department of Internal Medicine, Ewha Womans University Seoul Hospital, Seoul, Korea.
出版信息
Clin Endosc. 2022 Sep;55(5):581-587. doi: 10.5946/ce.2021.283. Epub 2022 Aug 29.
Abstract
Procedural sedation has become increasingly common in endoscopy. Sedatives and analgesics induce anxiolysis and amnesia. In addition, an appropriate level of sedation is necessary for safe procedures including therapeutic endoscopy. Midazolam and propofol are the most commonly used drugs in sedative endoscopy. In recent years, the need to ascertain the safety and effectiveness of sedation has increased in practice. Therefore, new sedatives and analgesic drugs for optimal sedative endoscopy, have recently emerged. This article reviews the characteristics of sedatives and analgesics, and describes their clinical use in gastrointestinal endoscopy.
摘要
在消化内镜检查中，程序性镇静已变得越来越普遍。镇静剂和镇痛药可诱导抗焦虑和失忆作用。此外，包括治疗性内镜检查在内的安全操作需要适当水平的镇静。咪达唑仑和丙泊酚是镇静性内镜检查中最常用的药物。近年来，在实践中确定镇静安全性和有效性的需求有所增加。因此，最近出现了用于优化镇静性内镜检查的新型镇静剂和镇痛药。本文综述了镇静剂和镇痛药的特性，并描述了它们在胃肠道内镜检查中的临床应用。
相似文献
1
New sedatives and analgesic drugs for gastrointestinal endoscopic procedures.用于胃肠内镜检查的新型镇静和镇痛药物。
Clin Endosc. 2022 Sep;55(5):581-587. doi: 10.5946/ce.2021.283. Epub 2022 Aug 29.
2
Procedural Sedation for Pediatric Upper Gastrointestinal Endoscopy in Korea.韩国儿科上消化道内镜检查的程序性镇静。
J Korean Med Sci. 2021 May 24;36(20):e136. doi: 10.3346/jkms.2021.36.e136.
3
Prescribing patterns of the four most commonly used sedatives in endoscopic examination in Korea: propofol, midazolam, diazepam, and lorazepam.韩国内镜检查中四种最常用镇静剂的处方模式：丙泊酚、咪达唑仑、地西泮和劳拉西泮。
Regul Toxicol Pharmacol. 2015 Apr;71(3):565-70. doi: 10.1016/j.yrtph.2015.01.007. Epub 2015 Feb 7.
4
Safe and effective procedural sedation for gastrointestinal endoscopy in children.儿童胃肠内镜检查的安全有效镇静。
J Pediatr Gastroenterol Nutr. 2012 Feb;54(2):171-85. doi: 10.1097/MPG.0b013e31823a2985.
5
Pre-procedural Preparation and Sedation for Gastrointestinal Endoscopy in Patients with Advanced Liver Disease.先进肝病患者胃肠内镜检查的术前准备和镇静。
Dig Dis Sci. 2022 Jul;67(7):2739-2753. doi: 10.1007/s10620-021-07111-1. Epub 2021 Jun 24.
6
Propofol versus midazolam and meperidine for conscious sedation in GI endoscopy.丙泊酚与咪达唑仑及哌替啶用于胃肠内镜检查中的清醒镇静
Am J Gastroenterol. 2000 Jun;95(6):1476-9. doi: 10.1111/j.1572-0241.2000.02080.x.
7
Propofol sedation for endoscopic procedures in children.丙泊酚用于儿童内镜检查的镇静
Endoscopy. 2000 Oct;32(10):788-91. doi: 10.1055/s-2000-7713.
8
[Sedation and analgesia during gastrointestinal endoscopy].[胃肠内镜检查期间的镇静与镇痛]
Orv Hetil. 2011 Mar 13;152(11):428-36. doi: 10.1556/OH.2011.29063.
9
Sedation and analgesia in gastrointestinal endoscopy: what's new?胃肠内镜中的镇静与镇痛：有哪些新进展？
World J Gastroenterol. 2010 May 28;16(20):2451-7. doi: 10.3748/wjg.v16.i20.2451.
10
Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children--blind randomised trial.丙泊酚-阿芬太尼与咪达唑仑-阿芬太尼用于诱导儿童上消化道内镜检查过程性遗忘的比较——盲法随机试验
Eur J Pediatr. 2015 Nov;174(11):1475-80. doi: 10.1007/s00431-015-2555-z. Epub 2015 May 9.
引用本文的文献
1
Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults.富马酸奥利替丁与瑞米唑仑联合给药对成人胃镜插入反应的有效剂量
Drug Des Devel Ther. 2025 Jun 10;19:5033-5041. doi: 10.2147/DDDT.S527586. eCollection 2025.
2
Remimazolam, a novel drug, for safe and effective endoscopic sedation.瑞马唑仑，一种新型药物，用于安全有效的内镜镇静。
Clin Endosc. 2025 May;58(3):370-376. doi: 10.5946/ce.2024.026. Epub 2025 Jan 14.
3
Comparative effects of ciprofol and propofol on perioperative outcomes: a systematic review and meta-analysis of randomized controlled trials.环丙泊酚与丙泊酚对围手术期结局的比较效果：一项随机对照试验的系统评价和荟萃分析
Braz J Anesthesiol. 2025 Mar-Apr;75(2):844578. doi: 10.1016/j.bjane.2024.844578. Epub 2024 Nov 26.
4
Optimal Surveillance of Metachronous Gastric Lesion after Endoscopic Resection of Early Gastric Cancer.早期胃癌内镜切除术后胃黏膜病变的最佳监测。
Gut Liver. 2024 Sep 15;18(5):781-788. doi: 10.5009/gnl240027. Epub 2024 Aug 8.
5
Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a prospective clinical study in Korea.用于预测胃肠内镜检查中镇静剂所致缺氧的模型开发：韩国的一项前瞻性临床研究
Clin Endosc. 2024 Jul;57(4):476-485. doi: 10.5946/ce.2023.198. Epub 2024 Apr 12.
6
Assessing wound complications in gastroscopy with Streptomyces protease enzyme combined with Shutai.评估胃镜检查中应用链霉蛋白酶酶与舒泰联合治疗的伤口并发症。
Int Wound J. 2024 Feb;21(2):e14577. doi: 10.1111/iwj.14577.
7
Up-to-date literature review and issues of sedation during digestive endoscopy.消化内镜检查期间镇静的最新文献综述及相关问题
Wideochir Inne Tech Maloinwazyjne. 2023 Sep;18(3):418-435. doi: 10.5114/wiitm.2023.127854. Epub 2023 Jun 1.
8
Clinical Practice Guideline for Percutaneous Endoscopic Gastrostomy.经皮内镜下胃造口术临床实践指南。
Gut Liver. 2024 Jan 15;18(1):10-26. doi: 10.5009/gnl230146. Epub 2023 Oct 18.
9
Clinical practice guidelines for percutaneous endoscopic gastrostomy.经皮内镜下胃造口术临床实践指南
Clin Endosc. 2023 Jul;56(4):391-408. doi: 10.5946/ce.2023.062. Epub 2023 Jun 23.
本文引用的文献
1
Efficacy and Safety of Remimazolam for Procedural Sedation: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.瑞米唑仑用于程序镇静的疗效和安全性：一项采用序贯试验分析的随机对照试验的荟萃分析
Front Med (Lausanne). 2021 Jul 27;8:641866. doi: 10.3389/fmed.2021.641866. eCollection 2021.
2
Efficacy and Safety of Remimazolam in Endoscopic Sedation-A Systematic Review and Meta-Analysis.瑞米唑仑用于内镜检查镇静的有效性和安全性——一项系统评价与Meta分析
Front Med (Lausanne). 2021 Jul 26;8:655042. doi: 10.3389/fmed.2021.655042. eCollection 2021.
3
Comparison of clinical efficacy and safety between dexmedetomidine and propofol among patients undergoing gastrointestinal endoscopy: a meta-analysis.地佐辛与丙泊酚用于胃肠镜检查的临床疗效和安全性比较：一项荟萃分析。
J Int Med Res. 2021 Jul;49(7):3000605211032786. doi: 10.1177/03000605211032786.
4
Procedural Sedation for Pediatric Upper Gastrointestinal Endoscopy in Korea.韩国儿科上消化道内镜检查的程序性镇静。
J Korean Med Sci. 2021 May 24;36(20):e136. doi: 10.3346/jkms.2021.36.e136.
5
The Use of Propofol versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy: A Meta-Analysis of Randomized Controlled Trials.丙泊酚与右美托咪定在接受药物诱导睡眠内镜检查患者中的应用：一项随机对照试验的荟萃分析
J Clin Med. 2021 Apr 9;10(8):1585. doi: 10.3390/jcm10081585.
6
Remimazolam tosilate in upper gastrointestinal endoscopy: A multicenter, randomized, non-inferiority, phase III trial.甲苯磺酸雷米佐仑用于上消化道内镜检查：一项多中心、随机、非劣效性、III 期临床试验。
J Gastroenterol Hepatol. 2021 Feb;36(2):474-481. doi: 10.1111/jgh.15188. Epub 2020 Jul 24.
7
Efficacy and Safety of Etomidate in Comparison with Propofol or Midazolam as Sedative for Upper Gastrointestinal Endoscopy.依托咪酯与丙泊酚或咪达唑仑相比作为上消化道内镜检查镇静剂的疗效和安全性
Clin Endosc. 2020 Sep;53(5):555-561. doi: 10.5946/ce.2019.210. Epub 2020 Mar 31.
8
Recent Developments in Drugs for GI Endoscopy Sedation.胃肠道内镜镇静药物的最新进展。
Dig Dis Sci. 2020 Oct;65(10):2781-2788. doi: 10.1007/s10620-020-06044-5. Epub 2020 Jan 8.
9
Safety and efficacy of combined use of propofol and etomidate for sedation during gastroscopy: Systematic review and meta-analysis.丙泊酚与依托咪酯联合用于胃镜检查镇静的安全性和有效性：系统评价与Meta分析
Medicine (Baltimore). 2019 May;98(20):e15712. doi: 10.1097/MD.0000000000015712.
10
Etomidate Sedation for Advanced Endoscopic Procedures.依托咪酯镇静用于先进的内镜检查。
Dig Dis Sci. 2019 Jan;64(1):144-151. doi: 10.1007/s10620-018-5220-3. Epub 2018 Jul 27.
Zotero 插件