Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Social Welfare, University of California, Los Angeles, CA, USA.
J Complement Integr Med. 2022 Aug 2;20(2):447-456. doi: 10.1515/jcim-2021-0537. eCollection 2023 Jun 1.
Adjuvant chemotherapy for breast cancer is undeniably effective in increasing survival rates but many breast cancer survivors (BCS) exhibit side effects including nausea, fatigue, stress, and neurocognitive deficits, known as "chemobrain." This pilot study explored how neurotherapy, or EEG biofeedback, a non-pharmacological approach, improved neurocognitive, behavioral, and neurophysiological deficits associated with BCS who underwent chemotherapy.
Subjects underwent 18 sessions of EEG biofeedback training, in which audio and visual feedback occurred with successful shifting of EEG patterns.
Quantitative EEG and assessment tests demonstrated neurophysiological, cognitive, and behavioral deficits in all nine subjects prior to training. EEG biofeedback resulted in significant improvements in neurophysiological, neurocognitive, and psychological functions in all nine subjects after training.
We propose that this intervention and related forms of EEG biofeedback have the potential to significantly alleviate common side effects of chemotherapy in BCS and therefore merits additional research attention.
乳腺癌辅助化疗无疑能提高生存率，但许多乳腺癌幸存者（BCS）表现出副作用，包括恶心、疲劳、压力和神经认知缺陷，即“化疗脑”。本初步研究探索了神经疗法（即脑电图生物反馈）这一非药物方法如何改善接受化疗的 BCS 患者与神经认知、行为和神经生理缺陷相关的问题。
受试者接受了 18 次脑电图生物反馈训练，在训练中，成功改变脑电图模式时会出现音频和视觉反馈。
在训练前，9 名受试者的定量脑电图和评估测试均显示出神经生理、认知和行为缺陷。脑电图生物反馈训练后，9 名受试者的神经生理、神经认知和心理功能均显著改善。
我们提出，这种干预措施和相关形式的脑电图生物反馈有可能显著缓解 BCS 化疗的常见副作用，因此值得进一步研究关注。
