Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Pathology, Harbin Medical University, Harbin, China.
Front Immunol. 2022 Aug 5;13:974821. doi: 10.3389/fimmu.2022.974821. eCollection 2022.
Neutrophil extracellular traps (NETs) are produced in large quantities at the site of inflammation, and they locally capture and eliminate various pathogens. Thus, NETs quickly control the infection of pathogens in the body and play vital roles in immunity and antibacterial effects. However, evidence is accumulating that NET formation can exacerbate pancreatic tissue damage during acute pancreatitis (AP). In this review, we describe the research progress on NETs in AP and discuss the possibility of NETs as potential therapeutic targets. In addition, since the current detection and visualization methods of NET formation are not uniform and the selection of markers is still controversial, a synopsis of these issues is provided in this review.
中性粒细胞胞外陷阱（NETs）在炎症部位大量产生，并局部捕获和消除各种病原体。因此，NETs 可以迅速控制体内病原体的感染，并在免疫和抗菌作用中发挥重要作用。然而，越来越多的证据表明，NET 的形成可加重急性胰腺炎（AP）时的胰腺组织损伤。在本综述中，我们描述了 NETs 在 AP 中的研究进展，并讨论了 NETs 作为潜在治疗靶点的可能性。此外，由于目前 NET 形成的检测和可视化方法并不统一，标志物的选择仍存在争议，因此在本综述中对这些问题进行了概述。
